Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pea15atm1Chne mutation
(1 available);
any
Pea15a mutation
(14 available)
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growth/size/body
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• homozygotes display a reduced body weight relative to wild-type littermates
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nervous system
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N |
• at 2 months of age, homozygotes display normal brain gross morphology and weight relative to wild-type mice
• no obvious differences are observed in the number, morphology, or organization of glial cells, as indicated by GFAP labeling of hippocampal astrocytes
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• in culture, primary astrocytes harvested from mutant mice are more sensitive to TNF-induced apoptosis than wild-type astrocytes, as indicated by DAPI, annexin V, and TUNEL staining
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pea15atm1Chne mutation
(1 available);
any
Pea15a mutation
(14 available)
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reproductive system
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• at 8 weeks of age, mutant testes show a significant increase in the number of apoptotic spermatocytes (stages IX and XI) relative to wild-type testes, as revealed by TUNEL analysis
• increased apoptosis of spermatocytes is not restricted to a specific step in spermatocyte development but occurs throughout the epithelial cycle
• in contrast to spermatocytes, spermatogonia remain relatively unaffected
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cellular
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• at 8 weeks of age, mutant testes show a significant increase in the number of apoptotic spermatocytes (stages IX and XI) relative to wild-type testes, as revealed by TUNEL analysis
• increased apoptosis of spermatocytes is not restricted to a specific step in spermatocyte development but occurs throughout the epithelial cycle
• in contrast to spermatocytes, spermatogonia remain relatively unaffected
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Analysis Tools