Phenotypes associated with this allele

• Allele Symbol: Igf2^tm1Wrk
• Allele Name: targeted mutation 1, Wolf Reik
• Allele ID: MGI:2677155
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2^tm1Wrk/Igf2^+	involves: 129P2/Ola * C57BL/6J	MGI:2677134

Genotype
MGI:2677134

ht1

• Allelic Composition: Igf2^tm1Wrk/Igf2⁺
• Genetic Background: involves: 129P2/Ola * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth retardation ( J:77386 )

• intrauterine growth retardation following onset of reduced placental growth

small placenta ( J:77386 , J:90697 )

• reduced placental growth (J:77386)

• placental maternal and fetal side-surface areas are reduced about 50% and harmonic mean thickness (a measure that emphasizes the presence of thin areas) is increased 128% compared to wild-type (J:90697)

decreased placenta weight ( J:90697 )

• placental weight is reduced to 72% and 66% of wild-type at E16 and E19 respectively

abnormal placental transport ( J:77386 , J:90697 )

• increased active transport initially compensates for reduction in permeability but by E19 this compensation no longer functions (J:77386)

• diffusion across the placenta is significantly reduced at E16 and over a greater range solute sizes at E19 at which time diffusion across the placenta is 45% of wild-type (J:90697)

growth/size/body

decreased birth body size ( J:65001 )

• mutants with a paternally inherited allele exhibit intrauterine growth retardation, with birth weights 71% that of normal mice

abnormal postnatal growth ( J:65001 )

• mutants with a paternally inherited allele, exhibit accelerated postnatal growth such that pups attain the weight of controls after weaning

abnormal prenatal growth/weight/body size ( J:77386 )

embryonic growth retardation ( J:77386 )

• intrauterine growth retardation following onset of reduced placental growth

decreased fetal weight ( J:90697 )

• fetal weight is reduced to 94% and 76% of wild-type at E16 and E19 respectively

cellular

maternal imprinting ( J:65001 , J:90697 )