All Phenotypes Igf2<tm1Rob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf2^tm1Rob
targeted mutation 1, Elizabeth J Robertson
MGI:2677156

Summary

45 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf2^tm1Rob/Igf2^tm1Rob	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820253
ht2	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3583358
ht3	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * BALB/c	MGI:2677281
ht4	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * C57BL/6 * DBA/2J	MGI:2677285
ht5	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * C57BL/6J	MGI:3845906
ht6	Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * MF1	MGI:2677279
ht7	Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820254
ht8	Igf2^tm1Rob/Igf2^tm4.1Wrk	involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6	MGI:5310742
cx9	Igf1^tm1Arge/Igf1^tm1Arge Igf2^tm1Rob/Igf2⁺	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)	MGI:3629689
cx10	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3629680
cx11	H19^tm1Tilg/H19⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv	MGI:3639341
cx12	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3845905
cx13	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629782
cx14	Gpc3^tm1Arge/Y Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629874
cx15	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3845907
cx16	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820260
cx17	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820262
cx18	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820263
cx19	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820272
cx20	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820273
cx21	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820274
cx22	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820275
cx23	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820276
cx24	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820277
cx25	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820278
cx26	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820279
cx27	Igf2^tm1Rob/Igf2^tm1Rob M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820294
cx28	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820295
cx29	Igf2^tm1Rob/Igf2^tm1Rob M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820296
cx30	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820297
cx31	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820301
cx32	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820302
cx33	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820303
cx34	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820304
cx35	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820305
cx36	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820306
cx37	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820307
cx38	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820308
cx39	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820259
cx40	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820255
cx41	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820258
cx42	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820261
cx43	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820257
cx44	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv	MGI:3820256
cx45	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺	involves: C57BL/6J * C57BL/6NTac	MGI:5505550

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:10453 , J:11007 , J:15108 , J:25091 , J:75054 )

• 40% reduction in body weight relative to wild-type littermates but only when the mutated allele is inherited paternally (J:10453)

• the rate of postnatal growth was similar to that of wild-type (J:10453)

• viable dwarfs with body weight 60% of normal when the mutated allele is inherited paternally (J:15108)

skeleton

delayed bone ossification ( J:15108 )

• when the mutated allele is inherited paternally, mutants exhibit a one day developmental delay in hyoid, cervical, and lumbar vertebrae, radius, ulna, femur, digits, nasal bone, and all cranial bones, except for the frontal and temporal bones

cellular

maternal imprinting ( J:11007 , J:15108 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• but only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, mice do not survive postnatally

lethality throughout fetal growth and development, incomplete penetrance ( J:77413 )

• some mice die between E14.5 and E18.5

cardiovascular system

abnormal heart morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles unlike in wild-type mice

abnormal heart septum morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice

increased heart weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

abnormal heart ventricle morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice

abnormal fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice

vision/eye

abnormal lens morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, minor lens abnormalities are observed

delayed eyelid fusion ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 5 of 14 mice have open eyelids at E16.5

embryo

increased placenta weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, placenta weight is 140% of wild-type mice at E15.5

endocrine/exocrine glands

adrenal gland cyst ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts

growth/size/body

increased heart weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

adrenal gland cyst ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts

omphalocele ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, 7 to 22 mice exhibit mild omphalocele consisting of a protrusion of only a small portion of the liver or of a mild herniation of only the gut

increased fetal weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, mice weight 140% of normal at E18.5

increased liver weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

homeostasis/metabolism

abnormal circulating hormone level ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, serum insulin-like growth factor II levels are increase compared to in wild-type mice

limbs/digits/tail

polydactyly ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone or an extra digits with two phalanges

• when Igf2^tm1Rob is inherited maternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly

liver/biliary system

increased hepatocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

increased liver weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

muscle

abnormal fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice

skeleton

abnormal sternum morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the ossification centers of the fourth sternebra are not fused along the midline and are underdeveloped compared to in wild-type mice at E17.5

abnormal xiphoid process morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the xiphisternum has unfused centers and is very broad compared to in wild-type mice

abnormal lumbar vertebrae morphology ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, the twin ossification centers in L3 are fused at E16.5

renal/urinary system

decreased kidney weight ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

cellular

abnormal fetal cardiomyocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice

increased hepatocyte proliferation ( J:77413 )

• when Igf2^tm1Rob is inherited maternally

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:11007 )

• but only when the mutated allele is inherited paternally

cellular

maternal imprinting ( J:11007 )

Allelic Composition	Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

• however, when this allele is inherited maternally mice exhibit normal placenta weight

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm4.1Wrk
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)
Igf2^tm4.1Wrk mutation (2 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal imprinting ( J:178292 )

• quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis of mRNA extracted from 8-10 pooled, whole 12.5-17.5 days post coitus (dpc) embryos with a nonfunctional paternal Igf2 allele demonstrates that those with a repressor binding site-disrupted maternal Igf2 allele express approximately 3-fold the amount of Igf2 mRNA as embryos with a normally repressed wild-type maternal allele; this is confirmed by RNAse protection analysis.

• while whole-embryo results primarily reflect expression in the mesoderm, analysis of placenta, yolk sac and endoderm-derived tissues including liver produces similar results.

growth/size/body

growth/size/body region phenotype ( J:169366 )

N	• unlike pups that inherit an Igf2 allele whose repressor binding site is disrupted by the floxed neo^r cassette, pups with the present, loxP-only disruption do not differ in size from their littermates.

Allelic Composition	Igf1^tm1Arge/Igf1^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1^tm1Arge mutation (2 available); any Igf1 mutation (29 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die shortly after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit the same developmental delays in the ossification of particular bones as the Igf1r^tm1Arge single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

thin epidermis stratum spinosum ( J:15108 )

• the stratum spinosum is underdeveloped in double mutants with a paternally inherited Igf2 allele

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure

growth/size/body

decreased birth weight ( J:15108 )

• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele

nervous system

abnormal nervous system morphology ( J:15108 )

• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants

respiratory system

respiratory failure ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants

cellular

maternal imprinting ( J:15108 )

• defects are seen in double mutants with a paternally inherited Igf2 allele

integument

abnormal epidermal layer morphology ( J:15108 )

• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants

Allelic Composition	H19^tm1Tilg/H19⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19^tm1Tilg mutation (1 available); any H19 mutation (12 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:25091 )

N	• indistinguishable in size from wild-type in birth weights and postnatal growth rates

Allelic Composition	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)
Rr28^tm1Tilg mutation (0 available); any Rr28 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77413 )

• when each allele is inherited maternally, mice begin to die at E14.5 and are all dead by E18.5

cardiovascular system

abnormal myocardium layer morphology ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles and atria unlike in wild-type mice

abnormal heart septum morphology ( J:77413 )

• when each allele is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice

increased heart weight ( J:77413 )

• when each allele is inherited maternally

abnormal heart ventricle morphology ( J:77413 )

• when each allele is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice

enlarged aortic valve ( J:77413 )

• when each allele is inherited maternally, the aortic valve is large and thickened compared to in wild-type mice

thick aortic valve ( J:77413 )

enlarged pulmonary valve ( J:77413 )

• when each allele is inherited maternally, the pulmonary valve is large and thickened compared to in wild-type mice

thick pulmonary valve ( J:77413 )

pericardial edema ( J:77413 )

• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice

abnormal fetal cardiomyocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice

vision/eye

abnormal lens development ( J:77413 )

• when each allele is inherited maternally, the anterior surface of the lens fiber cell fails to make contact with the interior surface of the lens epithelium at E13.5 to E17.5 leaving a position of the lumen unfilled unlike in wild-type mice

• when each allele is inherited maternally, severely affected mice exhibit abnormal suturing patterns

abnormal lens epithelium morphology ( J:77413 )

• poorly organized when each allele is inherited maternally

delayed eyelid fusion ( J:77413 )

• when each allele is inherited maternally, 12 of 13 mice have open eyelids at E16.5 and E17.5

liver/biliary system

increased hepatocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

increased liver weight ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

limbs/digits/tail

polydactyly ( J:77413 )

• when each allele is inherited maternally, penetrance of type B-like postaxial polydactyly is complete with a small extra digit that contains a single phalangeal bone

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone, an extra digits with two phalanges, or an extra digit with a third skeletal element

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly

embryo

increased placenta weight ( J:77413 )

• when each allele is inherited maternally, placenta weight is increased compared to in wild-type mice starting at E14.5

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, placenta weight is 140% of wild-type mice at E15.5

• when each allele is inherited maternally, placenta weight is 230% of wild-type at E16.5

craniofacial

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

endocrine/exocrine glands

adrenal gland cyst ( J:77413 )

• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities

homeostasis/metabolism

abnormal circulating hormone level ( J:77413 )

• when each allele is inherited maternally, serum insulin-like growth factor II levels are increase more than 11-fold compared to in wild-type mice

edema ( J:77413 )

• when each allele is inherited maternally, mice exhibit an edematous external appearance

pericardial edema ( J:77413 )

• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice

growth/size/body

increased heart weight ( J:77413 )

• when each allele is inherited maternally

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

adrenal gland cyst ( J:77413 )

• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities

omphalocele ( J:77413 )

• when each allele is inherited maternally, 20 of 22 mice exhibit large omphalocele consisting of a large portion of the liver present anteriorly and intestinal loops lying posteriorly

increased fetal weight ( J:77413 )

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, mice weight 130% of normal at E18.5

• when each allele is inherited maternally, mice weigh 200% of normal at E16.5 and E17.5

increased liver weight ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

muscle

abnormal myocardium layer morphology ( J:77413 )

abnormal fetal cardiomyocyte proliferation ( J:77413 )

skeleton

split sternum ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the sternum is split along the entire midline and almost duplicated in total width at E16.5

abnormal lumbar vertebrae morphology ( J:77413 )

• when each allele is inherited maternally, the twin centers in L2 are fused in the midline whereas the L3 and L4 centers remain separate at E16.5

• when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally, the twin ossification centers in L3 are fused at E16.5

digestive/alimentary system

cleft palate ( J:77413 )

• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate

renal/urinary system

decreased kidney weight ( J:77413 )

• when each allele is inherited maternally

cellular

abnormal fetal cardiomyocyte proliferation ( J:77413 )

increased hepatocyte proliferation ( J:77413 )

• when each allele is inherited maternally or when H19^tm2Tilg is inherited maternally and Igf2^tm1Rob is inherited paternally

Allelic Composition	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (18 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body size ( J:75054 )

• double mutants inheriting the mutant Igf2 allele paternally are larger than mice lacking Igf2

cellular

maternal imprinting ( J:75054 )

• defect is seen in double mutants that receive the Igf2 mutant allele from the father

Allelic Composition	Gpc3^tm1Arge/Y Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body size ( J:75054 )

• double mutants inheriting the mutant allele paternally are larger than mice lacking Igf2

cellular

maternal imprinting ( J:75054 )

• defect is seen in double mutants that receive the Igf2 mutant allele from the father

Allelic Composition	Rr28^tm1Tilg/Rr28⁺ Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Stw/Igf2r⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Stw mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)
Rr28^tm1Tilg mutation (0 available); any Rr28 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice die immediately after birth

limbs/digits/tail

polydactyly ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice exhibit postaxial polydactyly that is confined to a single forelimb

growth/size/body

increased fetal weight ( J:77413 )

• when Igf2r^tm1Stw and H19^tm2Tilg are inherited maternally and Igf2^tm1Rob is inherited paternally, mice weigh 135% of wild-type

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 73.8% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^tm1Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 73.8% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2r^tm2Arge is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2r^tm1Arge is inherited paternally, birth weight is 61.5% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 73.8% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r^tm1Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 73.8% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, birth weight is 73.8% of normal

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited paternally, birth weight is 61.5% of normal

increased birth weight ( J:34584 )

• when Igf2^tm1Rob and Igf2r^tm1Arge are inherited maternally, birth weight is 140% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)
M6pr^tm1Hlk mutation (0 available); any M6pr mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr^tm1Hlk
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice die within 4 weeks of birth

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

behavior/neurological

abnormal gait ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice exhibit a waddling gait

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm2Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2r^tm2Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, mice are fertile

Allelic Composition	Igf2^tm1Rob/Igf2⁺ Igf2r^tm1Arge/Igf2r⁺ M6pr^tm1Hlk/M6pr⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are viable

growth/size/body

decreased body size ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are dwarfed

reproductive system

reproductive system phenotype ( J:34584 )

N	• when Igf2^tm1Rob is inherited paternally and Igf2r^tm1Arge is inherited maternally, mice are fertile

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1Arge mutation (0 available); any Igf1r mutation (88 available)
Igf2r^tm2Arge mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, placenta size is 67% of normal at E18.5

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally and Igf2r^tm2Arge is inherited maternally, birth weight is 34.4% of normal

• when Igf2^tm1Rob and Igf2r^tm2Arge are inherited paternally, birth weight is 33.6% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob Igf2r^tm1Arge/Igf2r⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2r^tm1Arge is inherited maternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2⁺ Igf2r^tm2Arge/Igf2r^tm2Arge
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• when Igf2^tm1Rob is inherited paternally, birth weight is 34.4% of normal

Allelic Composition	Igf1r^tm1Arge/Igf1r^tm1Arge Igf2^tm1Rob/Igf2^tm1Rob
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

small placenta ( J:34584 )

• placenta size is 67% of normal at E18.5

growth/size/body

decreased birth weight ( J:34584 )

• birth weight is 33.6% of normal

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

growth/size/body

growth/size/body region phenotype ( J:197171 )

N	• rescue of postnatal overgrowth observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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