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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vpreb1atm1Shim
targeted mutation 1, Takeyuki Shimizu
MGI:2677163
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igll1tm1Shim/Igll1tm1Shim
Vpreb1atm1Shim/Vpreb1atm1Shim
Vpreb1btm1Shim/Vpreb1btm1Shim 		involves: 129P2/OlaHsd * C57BL/6 MGI:2677211


Genotype
MGI:2677211
cx1
Allelic
Composition		 Igll1tm1Shim/Igll1tm1Shim
Vpreb1atm1Shim/Vpreb1atm1Shim
Vpreb1btm1Shim/Vpreb1btm1Shim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igll1tm1Shim mutation (0 available); any Igll1 mutation (16 available)
Vpreb1atm1Shim mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Shim mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:76947 )
• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm
• numbers of nucleated bone marrow cells reduced
• no impairment of transition from immature to mature B cells
• no impairment of transition from pre-BII to immature B cells
• impaired transition from pre-BI to pre-BII
decreased immature B cell number ( J:76947 )
• reduced numbers of immature B cells
increased late pro-B cell number ( J:76947 )
• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells
decreased mature B cell number ( J:76947 )
• reduced numbers of mature B cells
decreased B-1a cell number ( J:76947 )
• reduced numbers of B1-a cells at 10 days of age
decreased pre-B cell number ( J:76947 )
• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)
• 7 fold decrease in large cells and 15 fold decrease in small cells

immune system
immune system phenotype ( J:76947 )
N
• serum levels of IgM were normal
abnormal B cell differentiation ( J:76947 )
• cultured bone marrow cells do not express Vpreb or Igl-5 either on the cell surface or in the cytoplasm
• numbers of nucleated bone marrow cells reduced
• no impairment of transition from immature to mature B cells
• no impairment of transition from pre-BII to immature B cells
• impaired transition from pre-BI to pre-BII
decreased immature B cell number ( J:76947 )
• reduced numbers of immature B cells
increased late pro-B cell number ( J:76947 )
• together with pre-BI cells, numbers increase 2 fold in cultured bone marrow cells
decreased mature B cell number ( J:76947 )
• reduced numbers of mature B cells
decreased B-1a cell number ( J:76947 )
• reduced numbers of B1-a cells at 10 days of age
decreased pre-B cell number ( J:76947 )
• pre-BII cells are severely decreased in numbers (25 fold at 3 weeks and 12 fold at 8-9 weeks)
• 7 fold decrease in large cells and 15 fold decrease in small cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory