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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb1tm1Cmn
targeted mutation 1, Carol A Mason
MGI:2677305
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb1tm1Cmn/Ephb1tm1Cmn involves: 129S1/Sv * 129X1/SvJ MGI:5306419
hm2
 		Ephb1tm1Cmn/Ephb1tm1Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677319
ht3
 		Ephb1tm1Cmn/Ephb1+ involves: 129S1/Sv * 129X1/SvJ MGI:5306418
ht4
 		Ephb1tm1Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677322
cx5
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129/Sv * CD-1 MGI:2677321
cx6
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5306604
cx7
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:5306605
cx8
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5306606
cx9
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2tm2Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:5306607
cx10
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3851502
cx11
 		Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3851503


Genotype
MGI:5306419
hm1
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:2677319
hm2
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal optic tract morphology ( J:85573 )
• marked reduction of the ipsilateral optic tract, by 43%, both at E17.5 and at birth
• axons from the ventrotemporal retina tend to cross the midline
• no obvious guidance errors in the optic nerve or tract other than ipsilateral reduction
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

vision/eye
vision/eye phenotype ( J:85573 )
N
• no intraretinal axon guidance errors observed in E17.5 embryos

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Genotype
MGI:5306418
ht3
Allelic
Composition		 Ephb1tm1Cmn/Ephb1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:2677322
ht4
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:85573 )
• express beta-gal in cells normally expressing Ephb1
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally

nervous system
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally




Genotype
MGI:2677321
cx5
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye

nervous system
abnormal optic tract morphology ( J:85573 )
• axons from ventrotemporal retina tend to cross the midline




Genotype
MGI:5306604
cx6
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306605
cx7
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306606
cx8
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm2Paw mutation (0 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306607
cx9
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm2Paw/Ephb2tm2Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm2Paw mutation (0 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit dorsal retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:3851502
cx10
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




Genotype
MGI:3851503
cx11
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm1Cmn
Ephb2tm1Paw/Ephb2tm1Paw
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (43 available)
Ephb2tm1Paw mutation (1 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective
abnormal axon morphology ( J:150550 )
• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

cellular
abnormal axon pruning ( J:150550 )
• mossy fiber pruning is defective




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory