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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata1tm1Phi
targeted mutation 1, Sjaak Philipsen
MGI:2677342
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata1tm1Phi/Gata1tm1Phi involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:2677347
cn2
 		Gata1tm1Phi/Y
Tg(Dhh-cre)1Mejr/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:2677349
cn3
 		Gata1tm1Phi/Gata1+
Tg(HBB-cre)1Phi/0
Tg(HBB-Gata1)G4Phi/0 		involves: FVB MGI:3579119
cn4
 		Gata1tm1Phi/Gata1+
Tg(HBB-cre)1Phi/0 		involves: FVB MGI:3579124
cx5
 		Gata1tm1Phi/Gata1+
Tg(HBB-Gata1)G4Phi/0 		involves: FVB MGI:3579126
ot6
 		Gata1tm1Phi/Y involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:2677348


Genotype
MGI:2677347
hm1
Allelic
Composition		 Gata1tm1Phi/Gata1tm1Phi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2677349
cn2
Allelic
Composition		 Gata1tm1Phi/Y
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:85598 )
• these mice were fertile and exhibited normal testicular development and spermatogenesis




Genotype
MGI:3579119
cn3
Allelic
Composition		 Gata1tm1Phi/Gata1+
Tg(HBB-cre)1Phi/0
Tg(HBB-Gata1)G4Phi/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
Tg(HBB-cre)1Phi mutation (0 available)
Tg(HBB-Gata1)G4Phi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:98277 )
• some mutant female embryos die by E13.5 - E14.0 and all are dead before birth similar to males hemizygous for Tg(HBB-Gata1)G4Phi

hematopoietic system
abnormal erythropoiesis ( J:98277 )
• definitive erythropoiesis is impaired with at least 2-fold more primitive cells compared to definitive cells present at E14.0
• compound mutant females are more severely affect compared to males hemizygous for Tg(HBB-Gata1)G4Phi and females heterozygous Gata1tm1Phi and hemizygous for Tg(HBB-cre)1Phi
• at E14.0, fewer cells beyond the polychromatic erythroblast stage are seen are seen in the liver and in hanging drop assays erythroid progenitors fail to differentiate
anemia ( J:98277 )
• most surviving mutant female embryos are anemic at E13.5 - E14.0 similar to males hemizygous for Tg(HBB-Gata1)G4Phi
• at E13.5, about 4% of the total circulating blood cells are immature erythroid precursors




Genotype
MGI:3579124
cn4
Allelic
Composition		 Gata1tm1Phi/Gata1+
Tg(HBB-cre)1Phi/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
Tg(HBB-cre)1Phi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythropoiesis ( J:98277 )
• definitive erythropoiesis is impaired
• at E14.0, fewer cells beyond the polychromatic erythroblast stage are seen are seen in the liver
• differentiation of erythroid progenitors in the hanging drop assay is intermediate between wild-type mice and males hemizygous for Tg(HBB-Gata1)G4Phi
anemia ( J:98277 )
• anemia is seen at E13.5 - E14.0; however, the rate of embryonic death is not increased compared to wild-type embryos
• anemia is transient (not present at birth), variable, and not as severe as in hemizygous males; however at E13.5, about 4% of the total circulating blood cells are immature erythroid precursors




Genotype
MGI:3579126
cx5
Allelic
Composition		 Gata1tm1Phi/Gata1+
Tg(HBB-Gata1)G4Phi/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
Tg(HBB-Gata1)G4Phi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythropoiesis ( J:98277 )
• the onset of definitive erythropoiesis is delayed with a lower ratio of definitive to primitive erythroid cells at E13.5 and E14.0
• differentiation of erythroid progenitors in the hanging drop assay is intermediate between wild-type mice and males hemizygous for Tg(HBB-Gata1)G4Phi




Genotype
MGI:2677348
ot6
Allelic
Composition		 Gata1tm1Phi/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Phi mutation (0 available); any Gata1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory