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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sirt1tm2Fwa
targeted mutation 2, Frederick W Alt
MGI:2677357
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sirt1tm2Fwa/Sirt1tm2Fwa involves: 129/Sv * 129S6/SvEvTac MGI:2677380


Genotype
MGI:2677380
hm1
Allelic
Composition		 Sirt1tm2Fwa/Sirt1tm2Fwa
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm2Fwa mutation (0 available); any Sirt1 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

vision/eye
abnormal eye morphology ( J:85542 )
• eye morphogenesis is dramatically perturbed, with multiple retinal involutions at E18.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory