All Phenotypes Sirt1<tm2.1Fwa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sirt1^tm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:2677369

Summary

2 genotypes

Allelic Composition	Sirt1^tm2.1Fwa/Sirt1^tm2.1Fwa
Genetic Background	FVB.129S6-Sirt1^tm2.1Fwa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1^tm2.1Fwa mutation (0 available); any Sirt1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:162852 )

N	• mice grow to adulthood without significant early mortality

growth/size/body

decreased body size ( J:162852 )

behavior/neurological

• in diet-restricted mice

Allelic Composition	Sirt1^tm2.1Fwa/Sirt1^tm2.1Fwa
Genetic Background	involves: 129/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1^tm2.1Fwa mutation (0 available); any Sirt1 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:85542 )

• eye morphogenesis is dramatically perturbed, with multiple retinal involutions at E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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