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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zap70tm1Dlo
targeted mutation 1, Dennis Y Loh
MGI:2677447
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zap70tm1Dlo/Zap70tm1Dlo involves: 129P2/OlaHsd MGI:3817860
ht2
 		Zap70m1Saka/Zap70tm1Dlo involves: 129P2/OlaHsd * BALB/c MGI:3698739
ht3
 		Zap70st/Zap70tm1Dlo involves: C57BL/6 MGI:3526700
cn4
 		Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/? 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3797235
cx5
 		Zap70m1Saka/Zap70tm1Dlo
Tg(Lck-ZAP70)824Saka/0 		involves: 129P2/OlaHsd * BALB/c MGI:3698747


Genotype
MGI:3817860
hm1
Allelic
Composition		 Zap70tm1Dlo/Zap70tm1Dlo
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-positive T cell number ( J:97610 )
• 95% of thymocytes are double positive T cells and CD69-

immune system
increased double-positive T cell number ( J:97610 )
• 95% of thymocytes are double positive T cells and CD69-




Genotype
MGI:3698739
ht2
Allelic
Composition		 Zap70m1Saka/Zap70tm1Dlo
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70m1Saka mutation (1 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune arthritis ( J:86607 )
• mice develop arthritis spontaneously by 3 months of age

skeleton
autoimmune arthritis ( J:86607 )
• mice develop arthritis spontaneously by 3 months of age




Genotype
MGI:3526700
ht3
Allelic
Composition		 Zap70st/Zap70tm1Dlo
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70st mutation (0 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage

immune system
arrested T cell differentiation ( J:41170 )
• thymocytes fail to mature beyond the double positive stage




Genotype
MGI:3797235
cn4
Allelic
Composition		 Syktm1Kuro/Syktm1Kuro
Zap70tm1Dlo/Zap70tm1Dlo
Cd79atm1(cre)Reth/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Syktm1Kuro mutation (0 available); any Syk mutation (42 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal pro-B cell differentiation ( J:134528 )
• there is a complete block pro-B cell differentation at the BP-1+HASlow stage

hematopoietic system
abnormal pro-B cell differentiation ( J:134528 )
• there is a complete block pro-B cell differentation at the BP-1+HASlow stage




Genotype
MGI:3698747
cx5
Allelic
Composition		 Zap70m1Saka/Zap70tm1Dlo
Tg(Lck-ZAP70)824Saka/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-ZAP70)824Saka mutation (0 available)
Zap70m1Saka mutation (1 available); any Zap70 mutation (55 available)
Zap70tm1Dlo mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:86607 )
• expression of transgene completely inhibits development of arthritis and corrects immunological abnormalities observed in Zap70-deficient mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory