Phenotypes associated with this allele

• Allele Symbol: Ern2^tm1Dron
• Allele Name: targeted mutation 1, David Ron
• Allele ID: MGI:2677494
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ern2^tm1Dron/Ern2^tm1Dron	either: 129S6/SvEvTac-Ern2^tm1Dron or B6.129S6-Ern2^tm1Dron	MGI:3687738

Genotype
MGI:3687738

hm1

• Allelic Composition: Ern2^tm1Dron/Ern2^tm1Dron
• Genetic Background: either: 129S6/SvEvTac-Ern2^tm1Dron or B6.129S6-Ern2^tm1Dron

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:67934 )

• development of intestinal inflammation occurs 3-5 days earlier when challenged with dextran sulfate than in controls

• more severe weight loss (28% vs 9% in controls)

• mortality also more rapid

• lesions more persistent into recovery period

• pathological changes most obvious in the distal large intestine including a marked shortening of the long axis

immune system

increased susceptibility to induced colitis ( J:67934 )

• development of intestinal inflammation occurs 3-5 days earlier when challenged with dextran sulfate than in controls

• more severe weight loss (28% vs 9% in controls)

• mortality also more rapid

• lesions more persistent into recovery period

• pathological changes most obvious in the distal large intestine including a marked shortening of the long axis