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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cntn2tm1Furl
targeted mutation 1, Andrew Furley
MGI:2677610
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cntn2tm1Furl/Cntn2tm1Furl involves: 129S1/Sv MGI:2677686
hm2
 		Cntn2tm1Furl/Cntn2tm1Furl involves: 129S1/Sv * C57BL/6 MGI:3832884
cx3
 		Mycbp2m7Bei/Mycbp2m7Bei
Cntn2tm1Furl/Cntn2+ 		involves: 129S1/Sv * A/J * C57BL/6 MGI:5505464
cx4
 		m8Bei/m8Bei
Cntn2tm1Furl/Cntn2+ 		involves: 129S1/Sv * A/J * C57BL/6 MGI:5505475


Genotype
MGI:2677686
hm1
Allelic
Composition		 Cntn2tm1Furl/Cntn2tm1Furl
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn2tm1Furl mutation (2 available); any Cntn2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sensory neuron innervation pattern ( J:137627 )
• developing embryos have aberrant projections of sensory afferents in the spinal cord
• significant numbers of aberrant projections from the dorsal funiculus to the dorsal horn are evident at E12.5 compared to virtually none in the wild-type controls
• the number of aberrant projections increase at E13.5 and again at E14.5 and remain at least 4-fold higher than controls
• by E14.5 the aberrant projections are also greater in length than controls with projections sometimes almost reaching the midline
• number of aberrant projections is more than what is observed in homozgyotes for L1cam null alleles
abnormal spinal cord dorsal horn morphology ( J:137627 )
• developing embryos have aberrant projections of sensory afferents from the dorsal funiculus to the dorsal horn
abnormal somatic nervous system physiology ( J:137627 )
• dorsal root ganglion cells are not repulsed by the presence of ventral spinal cord explants in the manner that wild-type controls are
• in culture, E13.5 sensory axons are refractory to repulsion mediated by Semaphorin-3A




Genotype
MGI:3832884
hm2
Allelic
Composition		 Cntn2tm1Furl/Cntn2tm1Furl
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn2tm1Furl mutation (2 available); any Cntn2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal sensory neuron innervation pattern ( J:137627 )
• developing embryos have aberrant projections of sensory afferents in the spinal cord
• significant numbers of aberrant projections from the dorsal funiculus to the dorsal horn are evident at E12.5 compared to virtually none in the wild-type controls
• the number of aberrant projections increase at E13.5 and again at E14.5 and remain at least 4-fold higher than controls
• by E14.5 the aberrant projections are also greater in length than controls with projections sometimes almost reaching the midline
• number of aberrant projections is more than what is observed in homozgyotes for L1cam null alleles
abnormal spinal cord dorsal horn morphology ( J:137627 )
• developing embryos have aberrant projections of sensory afferents from the dorsal funiculus to the dorsal horn
abnormal somatic nervous system physiology ( J:137627 )
• dorsal root ganglion cells are not repulsed by the presence of ventral spinal cord explants in the manner that wild-type controls are
• in culture, E13.5 sensory axons are refractory to repulsion mediated by Semaphorin-3A




Genotype
MGI:5505464
cx3
Allelic
Composition		 Mycbp2m7Bei/Mycbp2m7Bei
Cntn2tm1Furl/Cntn2+
Genetic
Background		 involves: 129S1/Sv * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn2tm1Furl mutation (2 available); any Cntn2 mutation (56 available)
Mycbp2m7Bei mutation (1 available); any Mycbp2 mutation (224 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal corpus callosum morphology ( J:199782 )
• midline crossing defect occasionally
abnormal striatum morphology ( J:199782 )
• aberrant patterning in the striatum
abnormal ventral striatum morphology ( J:199782 )
• corticofugal axon tracts in the ventral striatum

limbs/digits/tail




Genotype
MGI:5505475
cx4
Allelic
Composition		 m8Bei/m8Bei
Cntn2tm1Furl/Cntn2+
Genetic
Background		 involves: 129S1/Sv * A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cntn2tm1Furl mutation (2 available); any Cntn2 mutation (56 available)
m8Bei mutation (0 available); any m8Bei mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system tract morphology ( J:199782 )
• misdirected or fewer axon tracts than in controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory