All Phenotypes Hba<b3(th)> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hba^b3(th)
27HB deletion, Oak Ridge
MGI:2677681

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hba^b3(th)/Hba^b3(th)	SEC-Hba^b3(th)	MGI:3720089
ht2	Hba^b3(th)/Hba⁺	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	MGI:3720086
ht3	Hba^b3(th)/Hba⁺	involves: 101 * SEC	MGI:3720085
ht4	Hba^b3(th)/Hba⁺	involves: C57BL/6J * SEC	MGI:3720087
ht5	Hba^b3(th)/Hba⁺	SEC-Hba^b3(th)	MGI:3720088

Allelic Composition	Hba^b3(th)/Hba^b3(th)
Genetic Background	SEC-Hba^b3(th)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:6452 )

• most embryos appear to die between E.5. and E6.5

embryo

embryonic growth retardation ( J:6452 )

• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

trophectoderm cell degeneration ( J:6452 )

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

growth/size/body

embryonic growth retardation ( J:6452 )

• at 86h post mating most homozygous embryos are still in the morula stage while wild-type littermates have reached the blastocyst stage

• at E5.5 some embryos remain in the late blastocyst stage and these have pycnotic cells in the trophectoderm

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hypochromic microcytic anemia ( J:123943 )

increased erythrocyte cell number ( J:123943 )

decreased hematocrit ( J:123943 )

decreased hemoglobin content ( J:123943 )

decreased mean corpuscular hemoglobin ( J:123943 )

decreased mean corpuscular volume ( J:123943 )

• reduced mean cell volume despite increased red cell numbers

anisocytosis ( J:123943 )

acanthocytosis ( J:86011 )

anisopoikilocytosis ( J:86011 )

• red cells of irregular size and shape with pitted surfaces and blebs are seen

dacryocytosis ( J:86011 )

leptocytosis ( J:86011 )

• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls

microcytosis ( J:123943 )

• red cells are 75 - 80% the size of wild-type cells

poikilocytosis ( J:86011 )

• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

reticulocytosis ( J:123943 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:123943

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	involves: 101 * SEC

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hemoglobin ( J:5686 )

• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	involves: C57BL/6J * SEC

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:32654 )

• fewer than expected heterozygous mice are found at weaning (9% compared to the expected 50%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:32654

Allelic Composition	Hba^b3(th)/Hba⁺
Genetic Background	SEC-Hba^b3(th)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba^b3(th) mutation (0 available); any Hba mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:6452 )

• many pups die between birth and weaning

hematopoietic system

abnormal fetal derived definitive erythrocyte morphology ( J:6452 )

• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes

• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body

decreased birth body size ( J:6452 )

• newborn pups are smaller than wild-type littermates

decreased body weight ( J:6452 )

• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:6452

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24