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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccne2tm1Boa
targeted mutation 1, Bruno Amati
MGI:2677700
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccne2tm1Boa/Ccne2tm1Boa involves: 129/Sv * C57BL/6 MGI:2677715
cx2
 		Ccne1tm1Pisc/Ccne1tm1Pisc
Ccne2tm1Boa/Ccne2tm1Boa 		involves: 129/Sv * C57BL/6 MGI:2677716


Genotype
MGI:2677715
hm1
Allelic
Composition		 Ccne2tm1Boa/Ccne2tm1Boa
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne2tm1Boa mutation (0 available); any Ccne2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
small testis ( J:85497 )
• at 2 months of age the testis is 2/3 normal size

reproductive system
oligozoospermia ( J:85497 )
• 25-70% reduction in mature spermatozoa
small testis ( J:85497 )
• at 2 months of age the testis is 2/3 normal size

cellular
oligozoospermia ( J:85497 )
• 25-70% reduction in mature spermatozoa




Genotype
MGI:2677716
cx2
Allelic
Composition		 Ccne1tm1Pisc/Ccne1tm1Pisc
Ccne2tm1Boa/Ccne2tm1Boa
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2tm1Boa mutation (0 available); any Ccne2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:85497 )
• most are dead at E11.5
• 2 of 10 still had beating hearts at E11.5
• most double homozygotes were still alive at E10.5

cardiovascular system
abnormal vasculogenesis ( J:85497 )
• cranial vascularization at E10.5 like that typical at E9.5
abnormal vitelline vasculature morphology ( J:85497 )
• 60% showing poorly vascularized yolk sac at E11.5

embryo
abnormal vitelline vasculature morphology ( J:85497 )
• 60% showing poorly vascularized yolk sac at E11.5
abnormal trophoblast layer morphology ( J:85497 )
• reduced DNA content in trophoblast giant cells
• failure of endoreplication, few cells reach a ploidy of 8N

growth/size/body
abnormal embryonic growth/weight/body size ( J:85497 )
• no obvious morphological defects at E9.5-11.5
embryonic growth retardation ( J:85497 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory