Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^tm1Nesh
• Allele Name: targeted mutation 1, Norman E Sharpless
• Allele ID: MGI:2677722
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh	involves: 129S6/SvEvTac * FVB/N	MGI:3033694
cx2	Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh X/Tg(Tyr-HRAS)60Lc	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB	MGI:2676099

Genotype
MGI:3033694

hm1

• Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:88365 )

• mutants are more prone to spontaneous tumors than wild-type and Cdkn2a^tm2.1Rdp mice but less than Cdkn2a^tm1Rdp mice

increased incidence of tumors by chemical induction ( J:88365 )

• DMBA treatment results in the development of lymphoma, spindle cell tumors and lung tumors

increased small lymphocytic lymphoma incidence ( J:88365 )

• 33% of spontaneous tumors that form are lymphocytic lymphomas of the thymus and/or lymph nodes

• 60% of DMBA-induced tumors are lymphocytic lymphomas

increased lung carcinoma incidence ( J:88365 )

• 12% of spontaneous tumors that form in mutants are lung carcinomas

• 15% of DMBA-induced tumors are lung carcinomas; these tumors are larger are more likely to cause morbidity than in wild-type

increased sarcoma incidence ( J:88365 )

• 30% of spontaneous tumors that form in mutants are malignant spindle cell neoplasms, most likely soft tissue sarcomas

• 15% of DMBA-induced tumors are malignant spindle cell neoplasms

increased osteosarcoma incidence ( J:88365 )

• 9% of spontaneous tumors that form in mutants are osteosarcomas

• 3 of 6 mice with hind-limb paralysis showed osteosarcoma of the spine

behavior/neurological

hindlimb paralysis ( J:88365 )

• a few mice show hind-limb paralysis and seizures, however no glial tumors

seizures ( J:88365 )

• a few mice show hind-limb paralysis and seizures, however no glial tumors

cellular

abnormal cell physiology ( J:88365 )

• MEFs are susceptible to oncogenic transformation, show enhanced subcloning efficiency at low density, and resist both RAS- and culture-induced growth arrest

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:88365 )

• DMBA treatment results in the development of lymphoma, spindle cell tumors and lung tumors

nervous system

seizures ( J:88365 )

• a few mice show hind-limb paralysis and seizures, however no glial tumors

respiratory system

increased lung carcinoma incidence ( J:88365 )

• 12% of spontaneous tumors that form in mutants are lung carcinomas

• 15% of DMBA-induced tumors are lung carcinomas; these tumors are larger are more likely to cause morbidity than in wild-type

skeleton

increased osteosarcoma incidence ( J:88365 )

• 9% of spontaneous tumors that form in mutants are osteosarcomas

• 3 of 6 mice with hind-limb paralysis showed osteosarcoma of the spine

Genotype
MGI:2676099

cx2

• Allelic Composition: Cdkn2a^tm1Nesh/Cdkn2a^tm1Nesh; X/Tg(Tyr-HRAS)60Lc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

neoplasm

increased melanoma incidence ( J:85075 )

♂ • 40 week melanoma free survival as opposed to 89 weeks for wild-type mice

♂ • functioning of p16^INK4a was compromised in half of the tumors examined