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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncor1tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:2677822
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ncor1tm1Rsd/Ncor1tm1Rsd involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3028610
cx2
 		Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+ 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:3765909


Genotype
MGI:3028610
hm1
Allelic
Composition		 Ncor1tm1Rsd/Ncor1tm1Rsd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1Rsd mutation (1 available); any Ncor1 mutation (396 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:65417 )
• most embryos die by E15.5; no viable embryos found aby E18.5

embryo
decreased embryo size ( J:65417 )
• embryos are 50% smaller than littermates

growth/size/body
decreased embryo size ( J:65417 )
• embryos are 50% smaller than littermates

hematopoietic system
abnormal erythropoiesis ( J:65417 )
• defect in definitive but not primitive erythropoiesis
arrested T cell differentiation ( J:65417 )
• thymocytes are blocked in the CD4-/ CD8- stage; CD25+/ CD44- thymocytes were detected; cells can be induced to develop into CD4+/ CD8+ cells by treatment with anti-CD3epsilon antibodies
anemia ( J:65417 )
• increasing severity with age
decreased erythrocyte cell number ( J:65417 )
• fewer nonnucleated erythrocytes
decreased hematocrit ( J:65417 )
• apparent at E14.5
increased nucleated erythrocyte cell number ( J:65417 )
• increased number of nucleated erythroblasts

homeostasis/metabolism
edema ( J:65417 )
• seen in approximately 50% of embryos; progressive with age

immune system
arrested T cell differentiation ( J:65417 )
• thymocytes are blocked in the CD4-/ CD8- stage; CD25+/ CD44- thymocytes were detected; cells can be induced to develop into CD4+/ CD8+ cells by treatment with anti-CD3epsilon antibodies

liver/biliary system
abnormal hepatocyte morphology ( J:65417 )
• fetal liver cells have a reduced ability to form BFU-E colonies in culture
small liver ( J:65417 )
• the liver is half the size of wild-type

nervous system
small thalamus ( J:65417 )
• reduced overall size of the thalamus; small thalamic nuclei were noted including the lateral geniculate nuclei

integument
pallor ( J:65417 )
• noted in embryos from E13.5; probably due to anemia

endocrine/exocrine glands




Genotype
MGI:3765909
cx2
Allelic
Composition		 Ncor1tm1Rsd/Ncor1+
Ncor2tm1Rsd/Ncor2+
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1Rsd mutation (1 available); any Ncor1 mutation (396 available)
Ncor2tm1Rsd mutation (1 available); any Ncor2 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:127720 )
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells

cellular
abnormal neuron differentiation ( J:127720 )
• unlike in mice homozygous for either gene, cortical progenitor cells spontaneously differentiate into astroglia-like cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory