All Phenotypes Terf1<tm1Tdl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Terf1^tm1Tdl
targeted mutation 1, Titia de Lange
MGI:2677837

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Terf1^tm1Tdl/Terf1^tm1Tdl	involves: 129S2/SvPas	MGI:2677842
ht2	Terf1^tm1Tdl/Terf1⁺	involves: 129S2/SvPas	MGI:2677840
cx3	Terf1^tm1Tdl/Terf1^tm1Tdl Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas	MGI:2677843
cx4	Terc^tm1Rdp/Terc^tm1Rdp Terf1^tm1Tdl/Terf1^tm1Tdl	involves: 129S2/SvPas	MGI:2677844

Allelic Composition	Terf1^tm1Tdl/Terf1^tm1Tdl
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf1^tm1Tdl mutation (0 available); any Terf1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:85440 )

• no homozygotes born

• homozygotes die before E7.5

• 2 live homozygotes out of 10 found at E6.5

• E5-E5.5 litters with normal appearing homozygotes

embryo

abnormal inner cell mass apoptosis ( J:85440 )

• apoptosis occurring (around 62% of cells)

• no degradation of telomeric DNA or telomere fusions

absent inner cell mass proliferation ( J:85440 )

• ICM fail to grow after second day in culture from E3.5 embryos

abnormal extraembryonic tissue morphology ( J:85440 )

• extraembryonic structures generally aberrant

abnormal ectoplacental cone morphology ( J:85440 )

• at E6.5

cellular

abnormal inner cell mass apoptosis ( J:85440 )

• apoptosis occurring (around 62% of cells)

• no degradation of telomeric DNA or telomere fusions

absent inner cell mass proliferation ( J:85440 )

• ICM fail to grow after second day in culture from E3.5 embryos

Allelic Composition	Terf1^tm1Tdl/Terf1⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf1^tm1Tdl mutation (0 available); any Terf1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85440 )

• heterozygotes were slightly under represented in litters

• 58% as opposed to 66% expected

• no obvious phenotype and mice were fertile

• no chromosomal aberations and normal length telomeres both in MEFs and adult splenocytes

Allelic Composition	Terf1^tm1Tdl/Terf1^tm1Tdl Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf1^tm1Tdl mutation (0 available); any Terf1 mutation (37 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85440 )

• no homozygotes were born

• timing of lethality was somewhat attenuated

• undersized surviving embryos found at E7-7.5

• 2 surviving embryos at E8-8.5

embryo

disorganized extraembryonic tissue ( J:85440 )

• extraembryonic structures generally disorganized

Allelic Composition	Terc^tm1Rdp/Terc^tm1Rdp Terf1^tm1Tdl/Terf1^tm1Tdl
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terc^tm1Rdp mutation (4 available); any Terc mutation (8 available)
Terf1^tm1Tdl mutation (0 available); any Terf1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85440 )

• no homozygotes were born

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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