homeostasis/metabolism
• higher rectal temperature after cold challenge in mice fed a high-fat diet following a more significant drop in inguinal region
• however, response to is restored following oral or rectal administration of lactate
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• in fasted mice fed a high-fat diet
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• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal energy expenditure
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• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice
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• in the inguinal fat and epididymal fat of mice fed a high-fat diet after cold challenge along with increased mitochondrial CK activity
• however, treatment with lactate restores normal adaptive thermogenesis
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• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal RER
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• especially conjugated bile acids TCA and tauro-beta-muricholic acid, and precursor DCA in mice fed a high-fat diet compared with control mice
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digestive/alimentary system
• mice fed a high-fat diet exhibit inhibition of B. vulgatus and enrichment of R. torques associated with reduction in intestinal lactate levels compared with control mice
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adipose tissue
• in mice fed a high-fat diet
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growth/size/body
• in mice fed a high-fat diet
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• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice
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