Phenotypes associated with this allele

• Allele Symbol: Sftpa1^tm2Haw
• Allele Name: targeted mutation 2, Samuel Hawgood
• Allele ID: MGI:2677968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sftpa1^tm2Haw/Sftpa1^tm2Haw Sftpd^tm2Haw/Sftpd^tm2Haw	involves: C57BL/6J * CD-1	MGI:2677992

Genotype
MGI:2677992

cx1

• Allelic Composition: Sftpa1^tm2Haw/Sftpa1^tm2Haw; Sftpd^tm2Haw/Sftpd^tm2Haw
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased monocyte cell number ( J:86022 )

• increased macrophages in bronchoalveolar lavage fluid by week 6, dramatically increased at week 16

• patchy subpleural areas with abnormal macrophage accumulations, becoming very extensive by week 16

abnormal alveolar macrophage morphology ( J:86022 )

• alveolar macrophages grossly enlarged by week 16

immune system

increased monocyte cell number ( J:86022 )

• increased macrophages in bronchoalveolar lavage fluid by week 6, dramatically increased at week 16

• patchy subpleural areas with abnormal macrophage accumulations, becoming very extensive by week 16

abnormal alveolar macrophage morphology ( J:86022 )

• alveolar macrophages grossly enlarged by week 16

respiratory system

abnormal lung morphology ( J:86022 )

• progressive accumulation of phospholipids and protein in bronchoalveolar lavage fluid, significantly greater than in wild-type mice by week 6

• by week 16 accumulation of airspace secretions at significant levels

abnormal alveolar macrophage morphology ( J:86022 )

• alveolar macrophages grossly enlarged by week 16

abnormal pulmonary alveolus morphology ( J:86022 )

• abnormal cellular accumulations arising from alveoli and extending into the alveolar space by week 16

• enlarged air spaces and considerable size variability

abnormal pulmonary alveolus epithelium morphology ( J:86022 )

• epithelial surface area decreased indicating a loss of gas exchange surface per unit volume

thick pulmonary interalveolar septum ( J:86022 )

• septal thickening by week 16

homeostasis/metabolism

abnormal phospholipid level ( J:86022 )

• progressive accumulation of phospholipids in broncheolar lavage fluid is seen