mortality/aging
• 25% of homozygotes died during an exercise regimen of swimming compared to less than 5% of wild-type
|
cardiovascular system
• heart weight and heart/body weight ratios are increased by about 10%
|
• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers
• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter
|
• increased glucose uptake by the heart
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homeostasis/metabolism
hypoglycemia
(
J:54614
)
• increased glucose uptake by the heart leading to decreased plasma glucose levels
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• impaired long-chain fatty acid (LCFA) utilization by the heart, leading to increased glucose uptake by the heart
• associated with exercise intolerance
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behavior/neurological
• reduction in exercise tolerance, with homozygotes exhibiting much more exhaustion than wild-type after an exercise regimen of swimming
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muscle
• increased glucose uptake by the heart
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cellular
• increased glucose uptake by the heart
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growth/size/body
• heart weight and heart/body weight ratios are increased by about 10%
|
• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers
• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter
|