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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fabp3tm1Bin
targeted mutation 1, Bert Binas
MGI:2677970
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fabp3tm1Bin/Fabp3tm1Bin involves: 129P2/OlaHsd * BALB/c MGI:2677971


Genotype
MGI:2677971
hm1
Allelic
Composition
Fabp3tm1Bin/Fabp3tm1Bin
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fabp3tm1Bin mutation (1 available); any Fabp3 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 25% of homozygotes died during an exercise regimen of swimming compared to less than 5% of wild-type

cardiovascular system
• heart weight and heart/body weight ratios are increased by about 10%
• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers
• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter
• increased glucose uptake by the heart

homeostasis/metabolism
• increased glucose uptake by the heart leading to decreased plasma glucose levels
• impaired long-chain fatty acid (LCFA) utilization by the heart, leading to increased glucose uptake by the heart
• associated with exercise intolerance

behavior/neurological
• reduction in exercise tolerance, with homozygotes exhibiting much more exhaustion than wild-type after an exercise regimen of swimming

muscle
• increased glucose uptake by the heart

cellular
• increased glucose uptake by the heart

growth/size/body
• heart weight and heart/body weight ratios are increased by about 10%
• develop a regional cardiac hypertrophy at old age, which is restricted to the septum and ventricle muscle layers near the lumina of the heart chambers
• hypertrophy is accompanied by an enlargement of myocyte nuclei and muscle fiber diameter





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory