Phenotypes associated with this allele

• Allele Symbol: Apc^tm2Tno
• Allele Name: targeted mutation 2, Tetsuo Noda
• Allele ID: MGI:2678005
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apc^tm2Tno/Apc^+	involves: C57BL/6J	MGI:5521585
ht2	Apc^tm2Tno/Apc^+	Not Specified	MGI:2678020

Genotype
MGI:5521585

ht1

• Allelic Composition: Apc^tm2Tno/Apc⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestine polyps ( J:86036 )

• treatment with pioglitazone or bezafibrate suppresses polyp development

homeostasis/metabolism

increased circulating cholesterol level ( J:86036 )

• total cholesterol levels are increased between 6 and 12 weeks of age

increased circulating free fatty acids level ( J:86036 )

• free fatty acid levels are increased at 12 weeks of age

increased circulating triglyceride level ( J:86036 )

• triglyceride levels are increased after 6 weeks of age, with levels almost 10 times higher at 12 weeks of age than at 6 weeks of age

hyperlipidemia ( J:86036 )

• seen with age

• treatment with pioglitazone or bezafibrate decreases serum lipid levels and reduces severity of hepatic steatosis

liver/biliary system

hepatic steatosis ( J:86036 )

• centrilobular-restricted steatosis is seen in the livers of all mutants at 12 weeks of age, with numerous microvesicular fatty droplets in the cytoplasm of parenchymal cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial adenomatous polyposis		DOID:0050424	OMIM:PS175100	J:86036

Genotype
MGI:2678020

ht2

• Allelic Composition: Apc^tm2Tno/Apc⁺
• Genetic Background: Not Specified

neoplasm

increased intestinal adenoma incidence ( J:47857 )

• develop multiple intestinal adenomas throughout the duodenal-to-colonic axis

• treatment with piroxicam decreases the size and number of adenomas, while treatment with acarbose decreases only the size of adenomas

mortality/aging

premature death ( J:47857 )

• average lifespan of 120 days

digestive/alimentary system

increased intestinal adenoma incidence ( J:47857 )

• develop multiple intestinal adenomas throughout the duodenal-to-colonic axis

• treatment with piroxicam decreases the size and number of adenomas, while treatment with acarbose decreases only the size of adenomas