Phenotypes associated with this allele

• Allele Symbol: Pawr^tm1Jmos
• Allele Name: targeted mutation 1, Jorge Moscat
• Allele ID: MGI:2678021
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pawr^tm1Jmos/Pawr^tm1Jmos	involves: 129/Sv * CD-1	MGI:2678088

Genotype
MGI:2678088

hm1

• Allelic Composition: Pawr^tm1Jmos/Pawr^tm1Jmos
• Genetic Background: involves: 129/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased B cell proliferation ( J:85495 )

• increased proliferative response of B cells to activation by the B cell reseptor but not by LPS or CD40

increased T cell proliferation ( J:85495 )

• enhanced proliferation in response to antiCD3

• increased IL-2 production after antiCD3 stimulation

• there is a generally enhanced ability of T cells to proliferate

• reduced sensitivity of T cells to apoptotic challenge

enlarged spleen ( J:85495 )

• moderate splenomegaly due to a general increase in spleen cells

spleen hyperplasia ( J:85495 )

• leading to splenomegaly

increased lymphocyte cell number ( J:85495 )

abnormal T-helper 2 physiology ( J:85495 )

• overstimulation of IL-4 production and T helper 2 cells

immune system

increased B cell proliferation ( J:85495 )

• increased proliferative response of B cells to activation by the B cell reseptor but not by LPS or CD40

increased T cell proliferation ( J:85495 )

• enhanced proliferation in response to antiCD3

• increased IL-2 production after antiCD3 stimulation

• there is a generally enhanced ability of T cells to proliferate

• reduced sensitivity of T cells to apoptotic challenge

enlarged spleen ( J:85495 )

• moderate splenomegaly due to a general increase in spleen cells

spleen hyperplasia ( J:85495 )

• leading to splenomegaly

increased lymphocyte cell number ( J:85495 )

abnormal T-helper 2 physiology ( J:85495 )

• overstimulation of IL-4 production and T helper 2 cells

cellular

decreased sensitivity to induced cell death ( J:86034 )

• level of apoptosis induced in embryonic fibroblasts by TNF-alpha together with cyclohexamide is less than in wild-type mice

increased B cell proliferation ( J:85495 )

• increased proliferative response of B cells to activation by the B cell reseptor but not by LPS or CD40

increased T cell proliferation ( J:85495 )

• enhanced proliferation in response to antiCD3

• increased IL-2 production after antiCD3 stimulation

• there is a generally enhanced ability of T cells to proliferate

• reduced sensitivity of T cells to apoptotic challenge

growth/size/body

enlarged spleen ( J:85495 )

• moderate splenomegaly due to a general increase in spleen cells

spleen hyperplasia ( J:85495 )

• leading to splenomegaly