Phenotypes associated with this allele

• Allele Symbol: Unc5c^{rcmTg(Tert)5Hwl}
• Allele Name: transgene insertion 5, Han-Woong Lee
• Allele ID: MGI:2678074
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Unc5c^rcmTg(Tert)5Hwl/Unc5c^rcmTg(Tert)5Hwl	involves: FVB/N	MGI:2678090

Genotype
MGI:2678090

hm1

• Allelic Composition: Unc5c^{rcmTg(Tert)5Hwl}/Unc5c^{rcmTg(Tert)5Hwl}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat pad morphology ( J:85446 )

• reduced size of pericardial, perirenal, mesenteric, and epididymal fat depots

abnormal epididymal fat pad morphology ( J:85446 )

• reduced in size

behavior/neurological

increased fluid intake ( J:85446 )

• increased water intake

increased food intake ( J:85446 )

• increased food intake

ataxia ( J:85446 )

• forward motion is interrupted by frequent side-to-side swaying

abnormal gait ( J:85446 )

• swaying gait similar to that observed in Unc5c^rcm mice

hyperactivity ( J:85446 )

• increased travel distance and circling behavior within a chamber

increased locomotor activity ( J:85446 )

• increased travel distance within a chamber

growth/size/body

decreased body size ( J:85446 )

decreased body weight ( J:85446 )

• reduced weight putatively due to decrease in fat accumulation

• mice did not recover body weight in contrast to Unc5c^rcm mice which recovered body weight by 5 to 6 weeks of age

nervous system

abnormal cerebellum development ( J:85446 )

• decreased number of cerebellar lobules

abnormal corpora quadrigemina morphology ( J:85446 )

• ectopic cerebellar cells in the colliculus

• protrusion of colliculus

small cerebellum ( J:85446 )