Phenotypes associated with this allele

• Allele Symbol: Plk2^tm1Rle
• Allele Name: targeted mutation 1, Raymond L Erikson
• Allele ID: MGI:2678106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plk2^tm1Rle/Plk2^tm1Rle	either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * MF1)	MGI:2678107

Genotype
MGI:2678107

hm1

• Allelic Composition: Plk2^tm1Rle/Plk2^tm1Rle
• Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth retardation ( J:85756 )

• growth rate is similar to that of wild-type, and dwarfism is putatively due to defects in embryonic development

abnormal placenta labyrinth morphology ( J:85756 )

• labyrinthine zone at E18.5 is significantly smaller and exhibits reduced cell proliferation

decreased placenta weight ( J:85756 )

• average weight of placentas is about 70% of that of wild-type at E16.5 and this difference is maintained until birth

abnormal placenta development ( J:85756 )

• decreased cell proliferation in the labyrinth

growth/size/body

embryonic growth retardation ( J:85756 )

• growth rate is similar to that of wild-type, and dwarfism is putatively due to defects in embryonic development

decreased body size ( J:85756 )

• on average about 20% smaller than wild-type mice

decreased fetal weight ( J:85756 )

• fetuses are about 94% of the weight of normal embryos at E16.5 and E17.5 and reach 86% at E18.5

skeleton

delayed bone ossification ( J:85756 )

• ossification is delayed in the sternebrae and xiphoid process

• ossification of other bones occurs at the same time as it did in wild-type fetuses

vision/eye

eyelids open at birth ( J:85756 )

• ~30% are born with incompletely closed eyelids

cellular

abnormal cell cycle ( J:85756 )

• the cell cycle appears to be slightly delayed in embryonic fibroblasts cultured in vitro during early passages but by passage 6, they divide at the same rate as controls

• delay for cells in entering S phase from G1

integument

pallor ( J:85756 )

• skin is pale, although mutants do not appear to be anemic