Phenotypes associated with this allele

• Allele Symbol: Bdnf^tm1Sieg
• Allele Name: targeted mutation 1, Steven A Siegelbaum
• Allele ID: MGI:2678286
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Sieg/Bdnf^tm1Sieg	involves: 129S/SvEv * C57	MGI:2678290
cn2	Bdnf^tm1Sieg/Bdnf^tm1Sieg Tg(Camk2a-cre)1Szi/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:2678292
cn3	Bdnf^tm1Sieg/Bdnf^tm1Sieg Tg(Camk2a-cre)3Szi/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:2678309

Genotype
MGI:2678290

hm1

• Allelic Composition: Bdnf^tm1Sieg/Bdnf^tm1Sieg
• Genetic Background: involves: 129S/SvEv * C57

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85602 )

Genotype
MGI:2678292

cn2

• Allelic Composition: Bdnf^tm1Sieg/Bdnf^tm1Sieg; Tg(Camk2a-cre)1Szi/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

nervous system

reduced long-term potentiation ( J:85602 )

• significant decrease in the magnitude of LTP induced by 200 Hz tetanic stimulation, such that the mean field EPSP measured 1 hour after induction of LTP is enhanced to only 145% of its pretetanus level in mutants compared to 198% enhancement in controls

• the enhancement of FM 1-43 (a fluorescent marker of synaptic vesicle cycling) release from presynaptic terminals seen in controls during high-frequency (200 Hz) tetanic stimulation is blocked in mutants; rate of FM 1-43 release during low-frequency (50 Hz) tetanic stimulation is normal

• mutants exhibit a smaller magnitude of LTP 1 hour following theta burst stimulation, with an enhancement in the fEPSP to 136.7% of it's initial value compared to 166% in controls

Genotype
MGI:2678309

cn3

• Allelic Composition: Bdnf^tm1Sieg/Bdnf^tm1Sieg; Tg(Camk2a-cre)3Szi/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:85602 )

• mutants exhibit a normal hippocampus, normal lifespan and no defects in long term potentiation (LTP)