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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Top1tm1Unc
targeted mutation 1, University of North Carolina
MGI:2678314
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Top1tm1Unc/Top1tm1Unc involves: 129P2/OlaHsd * C57BL/6 MGI:2678320


Genotype
MGI:2678320
hm1
Allelic
Composition		 Top1tm1Unc/Top1tm1Unc
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Top1tm1Unc mutation (0 available); any Top1 mutation (210 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:36546 )
• development of homozygous mutant embryos arrests at the 4 to 16 cell stage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory