Phenotypes associated with this allele

• Allele Symbol: Pmaip1^tm1Ttg
• Allele Name: targeted mutation 1, Tadatsugu Taniguchi
• Allele ID: MGI:2678372
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pmaip1^tm1Ttg/Pmaip1^tm1Ttg	B6.129P2-Pmaip1^tm1Ttg	MGI:2678375

Genotype
MGI:2678375

hm1

• Allelic Composition: Pmaip1^tm1Ttg/Pmaip1^tm1Ttg
• Genetic Background: B6.129P2-Pmaip1^tm1Ttg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:85569 )

• life span om mutants after X-ray irradiation is significantly longer than that of wild-type mice

cellular

decreased sensitivity to induced cell death ( J:85569 )

• MEFs are more resistant to etoposide, adriamycin or cisplatin induced apoptosis than wild-type MEFs

decreased cellular sensitivity to X-ray irradiation ( J:85569 )

• mutants exhibit increased resistance to X-ray irradiation-induced gastrointestinal death, showing suppressed apoptosis of the epithelial cells of small intestinal crypts and cells in the lamina propria

decreased cellular sensitivity to ultraviolet irradiation ( J:85569 )

• MEFs are more resistant to UV-induced apoptosis than wild-type MEFs

neoplasm

neoplasm ( J:85569 )

N • mutants do not exhibit any signs of tumorigenesis in the first year of life

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:85569 )

• life span om mutants after X-ray irradiation is significantly longer than that of wild-type mice