Analysis Tools
immune system
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• although vacuolating cytotoxin VacA produced by Helicobacter pylori is incorporated into gastric epithelial cells to the same extent as in wild-type mice, homozygotes do not show gastric ulcers or other mucosal damage as wild-type mice do
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behavior/neurological
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• mice exhibit a slower rate of spatial learning at 20 weeks of age but not at 8 weeks of age
• in the hidden-platform task of the Morris water maze, the overall escape latencies of mutants are longer than those of wild-type mice
• in the transfer test of the Morris water maze, mutants show a decrease in the time spent in the trained quadrant compared to wild-type mice
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nervous system
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• long term potentiation (LTP) is enhanced in the CA1 region of the hippocampus in adults
• however, enhanced LTP is not due to modification of NMDA receptor properties
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