Phenotypes associated with this allele

• Allele Symbol: Opn1mw^{tm1(OPN1LW)Nat}
• Allele Name: targeted mutation 1, Jeremy Nathans
• Allele ID: MGI:2678763
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opn1mw^tm1(OPN1LW)Nat/Opn1mw^tm1(OPN1LW)Nat	involves: 129	MGI:2678773
ht2	Opn1mw^tm1(OPN1LW)Nat/Opn1mw^+	involves: 129	MGI:2678771
cx3	Opn1mw^tm1(OPN1LW)Nat/Opn1mw^tm1(OPN1LW)Nat Opn4^tm1Yau/Opn4^tm1Yau	involves: 129	MGI:5694632
ot4	Opn1mw^tm1(OPN1LW)Nat/Y	involves: 129	MGI:2678774

Genotype
MGI:2678773

hm1

• Allelic Composition: Opn1mw^{tm1(OPN1LW)Nat}/Opn1mw^{tm1(OPN1LW)Nat}
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal vision ( J:85849 )

♀ • retinal ganglion cells show spectral sensitivity matching that of the human red pigment (approximate 45-nm red shift) instead of the native mouse green pigment

Genotype
MGI:2678771

ht2

• Allelic Composition: Opn1mw^{tm1(OPN1LW)Nat}/Opn1mw⁺
• Genetic Background: involves: 129

vision/eye

abnormal vision ( J:85849 )

♀ • retinal multielectrode array recordings show significant variation in the chromatic sensitivities of retinal ganglion cells, receiving a mixture of input from the red and green pigments

Genotype
MGI:5694632

cx3

• Allelic Composition: Opn1mw^{tm1(OPN1LW)Nat}/Opn1mw^{tm1(OPN1LW)Nat}; Opn4^tm1Yau/Opn4^tm1Yau
• Genetic Background: involves: 129

vision/eye

abnormal visual contrast sensitivity ( J:199509 )

• mice learn to swim toward higher radiance target, green vs red or dim red vs brighter red

• mice no longer distinguish between green and red targets at a higher green radiance level than do mice homozygous only for Opn1mw^{tm1(OPN1LW)Nat}

Genotype
MGI:2678774

ot4

• Allelic Composition: Opn1mw^{tm1(OPN1LW)Nat}/Y
• Genetic Background: involves: 129

vision/eye

abnormal vision ( J:85849 )

♂ • retinal ganglion cells show spectral sensitivity matching that of the human red pigment (approximate 45-nm red shift) instead of the native mouse green pigment