Phenotypes associated with this allele

• Allele Symbol: Traf6^tm1Ywc
• Allele Name: targeted mutation 1, Yongwon Choi
• Allele ID: MGI:2678775
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf6^tm1Ywc/Traf6^tm1Ywc	Not Specified	MGI:2678795

Genotype
MGI:2678795

hm1

• Allelic Composition: Traf6^tm1Ywc/Traf6^tm1Ywc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:85808 )

• mice typically die by 3 weeks of age

growth/size/body

decreased body size ( J:85808 )

• progressive runting

enlarged spleen ( J:85808 )

hematopoietic system

abnormal dendritic cell differentiation ( J:85808 )

• impaired dendritic cell maturation and development

• absence of CD4⁺CD8alpha^- dendritic cells

thymus atrophy ( J:85808 )

decreased dendritic cell number ( J:85808 )

• lower frequency of CD11c^high dendritic cells (DCs) in 2 week old mutants

• 5.6-fold reduction in the total number of splenic DCs compared to controls

• CD4+ DC population is almost absent (31-fold reduction)

• 5.5-fold reduction of CD8alpha+ DCs

• 3.3-fold reduction of double negative dendritic cells

abnormal spleen morphology ( J:85808 )

• spleens are disorganized, with complete absence of normal T and B cell areas

• distinct periarteriolar or lymphoid collections are absent although small clumps of lymphocytes are scattered throughout the spleen

enlarged spleen ( J:85808 )

absent spleen white pulp ( J:85808 )

• spleens lacked T and B cell areas

immune system

abnormal dendritic cell differentiation ( J:85808 )

• impaired dendritic cell maturation and development

• absence of CD4⁺CD8alpha^- dendritic cells

thymus atrophy ( J:85808 )

decreased dendritic cell number ( J:85808 )

• lower frequency of CD11c^high dendritic cells (DCs) in 2 week old mutants

• 5.6-fold reduction in the total number of splenic DCs compared to controls

• CD4+ DC population is almost absent (31-fold reduction)

• 5.5-fold reduction of CD8alpha+ DCs

• 3.3-fold reduction of double negative dendritic cells

abnormal spleen morphology ( J:85808 )

• spleens are disorganized, with complete absence of normal T and B cell areas

• distinct periarteriolar or lymphoid collections are absent although small clumps of lymphocytes are scattered throughout the spleen

enlarged spleen ( J:85808 )

absent spleen white pulp ( J:85808 )

• spleens lacked T and B cell areas

abnormal lymph node morphology ( J:85808 )

abnormal dendritic cell physiology ( J:85808 )

• LPS-treated DCs do not exhibit enhanced capacity to stimulate naive T cells

• dendritic cells fail to induce peptide antigen-specific T cell responses

decreased interleukin-12 secretion ( J:85808 )

• production of IL-12 p40 by dendritic cells in response to stimulation is impaired

decreased interleukin-6 secretion ( J:85808 )

• production of IL-6 by dendritic cells in response to stimulation is impaired

skeleton

osteopetrosis ( J:85808 )

• severe

cellular

abnormal dendritic cell differentiation ( J:85808 )

• impaired dendritic cell maturation and development

• absence of CD4⁺CD8alpha^- dendritic cells

endocrine/exocrine glands

thymus atrophy ( J:85808 )