Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ikbkbtm1Cgn targeted mutation 1, University of Cologne MGI:2678815 |
| Summary |
11 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• B cell turnover over a one week period is almost twice that of controls
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• immature B cell numbers in the spleen are reduced by about a half
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• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
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• B-1 B cell numbers are strongly decreased in the peritoneum cavity
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• follicular B cells are the most diminished B cell population in the spleen
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• marginal zone B cell numbers are reduced about 4-fold
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• B cell turnover over a one week period is almost twice that of controls
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• immature B cell numbers in the spleen are reduced by about a half
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• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
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• B-1 B cell numbers are strongly decreased in the peritoneum cavity
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• follicular B cells are the most diminished B cell population in the spleen
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• marginal zone B cell numbers are reduced about 4-fold
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• B cell turnover over a one week period is almost twice that of controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice reach adulthood without showing inflammatory skin lesions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice reach adulthood without showing inflammatory skin lesions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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• at P7
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• milder at P7 than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice survive to adulthood
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
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• at P8, milder than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• spleen and lymph nodes are nearly devoid of T cells
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• only a mild reduction in the CD4 single-positive cells in the thymus
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• 50% reduction in CD8 single-positive cells in the thymus
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• loss of single positive thymocytes during final maturation stages in the thymus
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• spleen and lymph nodes are nearly devoid of T cells
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• only a mild reduction in the CD4 single-positive cells in the thymus
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• 50% reduction in CD8 single-positive cells in the thymus
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• loss of single positive thymocytes during final maturation stages in the thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe inflammation requiring euthanasia by P25 in some mice
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
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• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• before P9
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• severe
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• severe
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• severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4+ T cell numbers are reduced in the spleen and lymph nodes
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• CD8+ T cell numbers are reduced in the spleen and lymph nodes
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• CD4+ T cell numbers are reduced in the spleen and lymph nodes
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• CD8+ T cell numbers are reduced in the spleen and lymph nodes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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