Phenotypes associated with this allele

• Allele Symbol: Tg(K5-Ptgs2)675Kmd
• Allele Name: transgene insertion 675, Karin Muller-Decker
• Allele ID: MGI:2679341
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(K5-Ptgs2)675Kmd/Tg(K5-Ptgs2)675Kmd	involves: NMRI	MGI:2679345
tg2	Tg(K5-Ptgs2)675Kmd/0	involves: NMRI	MGI:3712654

Genotype
MGI:2679345

tg1

• Allelic Composition: Tg(K5-Ptgs2)675Kmd/Tg(K5-Ptgs2)675Kmd
• Genetic Background: involves: NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:85979 )

• sebaceous gland hyperplasia becomes apparent around P29

integument

sebaceous gland hyperplasia ( J:85979 )

• sebaceous gland hyperplasia becomes apparent around P29

alopecia ( J:85979 )

• develop alopecia at 3-10 months of age

sparse hair ( J:85979 )

• sparse hair coat early after birth

abnormal hair follicle morphology ( J:85979 )

• loss of hair follicles

abnormal hair cycle ( J:85979 )

• precocious entry into the catagen phase of the first hair growth cycle and subsequent irregular hair follicle phasing, such that at P49, catagen hair follicles are predominant instead of telogen

Genotype
MGI:3712654

tg2

• Allelic Composition: Tg(K5-Ptgs2)675Kmd/0
• Genetic Background: involves: NMRI

Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

mortality/aging

premature death ( J:70039 )

• die at 10 months of age

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:70039 )

• sebaceous gland hyperplasia

• most pronounced in dorsal and tail skin

homeostasis/metabolism

increased prostaglandin level ( J:70039 )

• increased prostaglandin levels

integument

sebaceous gland hyperplasia ( J:70039 )

• sebaceous gland hyperplasia

• most pronounced in dorsal and tail skin

abnormal coat/ hair morphology ( J:70039 )

abnormal coat appearance ( J:70039 )

• at 7 weeks of age fur appeared sparse, greasy, and coarse

• hair phenotype most severe on the back

alopecia ( J:70039 )

• hairless at 8 days of age

sparse hair ( J:70039 )

coarse hair ( J:70039 )

greasy coat ( J:70039 )

abnormal nail morphology ( J:70039 )

long toenails ( J:70039 )

abnormal hair follicle development ( J:70039 )

• delayed hair follicle maturation

abnormal hair follicle orientation ( J:70039 )

• hair follicles oriented perpendicular to skin

decreased hair follicle number ( J:70039 )

abnormal dermal layer morphology ( J:70039 )

• increased blood vessel density in upper dermis

hyperkeratosis ( J:70039 )

• epidermal hyperkeratosis of the tail

epidermal hyperplasia ( J:70039 )

• epidermal hyperplasia of the tail

thin skin ( J:70039 )

limbs/digits/tail

long toenails ( J:70039 )