About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crebbptm1Reck
targeted mutation 1, Richard Eckner
MGI:2679376
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Crebbptm1Reck/Crebbp+ involves: 129P2/OlaHsd MGI:2679423


Genotype
MGI:2679423
ht1
Allelic
Composition		 Crebbptm1Reck/Crebbp+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1Reck mutation (0 available); any Crebbp mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:85949 )
• about 10% of embryos die between E12.5 and E15.5
postnatal lethality, complete penetrance ( J:85950 )
• neonates do not survive beyond 1 or 2 days following birth
embryonic lethality during organogenesis, incomplete penetrance ( J:85949 )
• about 10% of embryos die between E12.5 and E15.5

cardiovascular system
thin ventricle myocardium compact layer ( J:85949 )
• compact layer of the ventricles is moderately thinner than in wild-type
abnormal heart development ( J:85949 )
• less severe than in Ep300tm1Reck heterozygotes

muscle
muscle phenotype ( J:85950 )
N
• mutants appear to have normal myogenesis
thin ventricle myocardium compact layer ( J:85949 )
• compact layer of the ventricles is moderately thinner than in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory