Phenotypes associated with this allele

• Allele Symbol: Drd2^{tm1(IL2RA)Koba}
• Allele Name: targeted mutation 1, Kazuto Kobayashi
• Allele ID: MGI:2679435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Drd2^tm1(IL2RA)Koba/Drd2^+	B6.129P2-Drd2^tm1(IL2RA)Koba	MGI:3719696

Genotype
MGI:3719696

ht1

• Allelic Composition: Drd2^{tm1(IL2RA)Koba}/Drd2⁺
• Genetic Background: B6.129P2-Drd2^{tm1(IL2RA)Koba}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor activation ( J:85929 )

• after methamphetamine treatment, mice exhibit less of an increase in movement relative to wild-type mice

• mice exhibit a greater amount of spontaneous movement

unidirectional circling ( J:85929 )

• following treatment with IT injection, mice turn more towards the side of injection relative to wild-type mice and the direction of turning could be reversed by methamphetamine treatment

• following treatment with IT injection and treatment with apomorphine mice turn ispilaterally to the injection

nervous system

decreased dopaminergic neuron number ( J:85929 )

• following treatment with IT injection, the number of D2R containing neurons are 2.6% of that in wild-type mice