Phenotypes associated with this allele

• Allele Symbol: Bmp5^cfe-se7J
• Allele Name: cauliflower ear short ear 7 Jackson
• Allele ID: MGI:2679550
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp5^cfe-se7J/Bmp5^cfe-se7J	involves: 129S7/SvEvBrd * BALB/cJ	MGI:3716546

Genotype
MGI:3716546

hm1

• Allelic Composition: Bmp5^cfe-se7J/Bmp5^cfe-se7J
• Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal cranium morphology ( J:123049 )

• male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height

• the skull length to nose length ratio is decreased in females

• the skull height to skull length ratio is increased in males

• the skull length to skull width ratio is decreased in both males and females

• the skull height to skull width ratio is increased in males

abnormal cranium size ( J:223062 )

• slight but significant decrease in the skull length to width ratio

decreased cranium height ( J:123049 )

• males and females have shorter skull lengths than do controls

decreased cranium length ( J:223062 )

• slightly smaller skull length in both males and females

short mandible ( J:123049 , J:223062 )

• shortened lower jaw length is statistically significant in females, but not statistically significant in males (J:123049)

♀ (J:223062)

short maxilla ( J:123049 )

• shortened upper jaw length is statistically significant in males, but not statistically significant in females

abnormal nose morphology ( J:123049 )

• females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant

short snout ( J:123049 , J:223062 )

♀ • the slightly shorter snout reaches statistical significance in females (J:123049)

lowered ear position ( J:123049 )

abnormal ear shape ( J:123049 )

• both ears are smaller than normal and have round ear pinnae with ridges around the perimeter

short ears ( J:223062 )

• both females and males have ear lobes that are approximately half normal length

skeleton

skeleton phenotype ( J:123049 )

N • no abnormality was found in spine length, ratios of tail length to back length, femur length to back length or spine length to back length

abnormal cranium morphology ( J:123049 )

• male homozygotes have greater skull height than controls, but female homozygotes have a statistically insignificant decrease in skull height

• the skull length to nose length ratio is decreased in females

• the skull height to skull length ratio is increased in males

• the skull length to skull width ratio is decreased in both males and females

• the skull height to skull width ratio is increased in males

abnormal cranium size ( J:223062 )

• slight but significant decrease in the skull length to width ratio

decreased cranium height ( J:123049 )

• males and females have shorter skull lengths than do controls

decreased cranium length ( J:223062 )

• slightly smaller skull length in both males and females

short mandible ( J:123049 , J:223062 )

• shortened lower jaw length is statistically significant in females, but not statistically significant in males (J:123049)

♀ (J:223062)

short maxilla ( J:123049 )

• shortened upper jaw length is statistically significant in males, but not statistically significant in females

decreased bone mineral content ( J:223062 )

• statistically slightly lower in both females and males

decreased bone mineral density ( J:123049 )

• whole body bone mineral density is decreased in both females and males

decreased areal bone mineral density ( J:223062 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:123049 )

N • ABR threshold analysis at three months of age indicates normal hearing

lowered ear position ( J:123049 )

abnormal ear shape ( J:123049 )

• both ears are smaller than normal and have round ear pinnae with ridges around the perimeter

short ears ( J:223062 )

• both females and males have ear lobes that are approximately half normal length

respiratory system

abnormal nose morphology ( J:123049 )

• females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant

growth/size/body

abnormal nose morphology ( J:123049 )

• females have shorter nose lengths than controls, but the shortened nose lenghts of male homozygotes was not found statistically significant

short snout ( J:123049 , J:223062 )

♀ • the slightly shorter snout reaches statistical significance in females (J:123049)

lowered ear position ( J:123049 )

abnormal ear shape ( J:123049 )

• both ears are smaller than normal and have round ear pinnae with ridges around the perimeter

short ears ( J:223062 )

• both females and males have ear lobes that are approximately half normal length