Phenotypes associated with this allele

• Allele Symbol: Pak5^tm1Amin
• Allele Name: targeted mutation 1 Audrey Minden
• Allele ID: MGI:2679653
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak5^tm1Amin/Pak5^tm1Amin	involves: 129P2/OlaHsd	MGI:3821626
hm2	Pak5^tm1Amin/Pak5^tm1Amin	involves: 129P2/OlaHsd * C57BL/6	MGI:2679705
cx3	Pak6^tm1Amin/Pak6^tm1Amin Pak5^tm1Amin/Pak5^tm1Amin	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3821625

Genotype
MGI:3821626

hm1

• Allelic Composition: Pak5^tm1Amin/Pak5^tm1Amin
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal active avoidance behavior ( J:141962 )

• mice exhibit reduced learning of active avoidance behaviors in a T-maze test compared to wild-type mice but not as reduced as in Pak6^tm1Amin Pak7^tm1Amin homozygotes

Genotype
MGI:2679705

hm2

• Allelic Composition: Pak5^tm1Amin/Pak5^tm1Amin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:85956 )

N • mice are viable

reproductive system

reproductive system phenotype ( J:85956 )

N • mice are fertile

nervous system

nervous system phenotype ( J:85956 )

N • mice exhibit a normal nervous system

Genotype
MGI:3821625

cx3

• Allelic Composition: Pak6^tm1Amin/Pak6^tm1Amin; Pak5^tm1Amin/Pak5^tm1Amin
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:141962 )

N • despite locomotor deficits, mice exhibit normal balance, coordination and anxiety levels

abnormal active avoidance behavior ( J:141962 )

• mice exhibit reduced learning of active avoidance behaviors in a T-maze test compared to wild-type mice

• in a T-maze mice exhibit longer avoidance time than wild-type mice

impaired passive avoidance behavior ( J:141962 )

• mice perform worse than wild-type mice in a passive avoidance T-maze test and exhibit increased time to make the incorrect response compared to wild-type mice

decreased exploration in new environment ( J:141962 )

• mice fail to exhibit an increase in locomotor activity when exposed to a novel environment

decreased aggression towards male mice ( J:141962 )

• when exposed to a male intruder, male mice initiate fewer attacks and exhibit increased latency to attack compared to wild-type mice

• however, serotonine and dopamine levels are normal

decreased grip strength ( J:141962 )

• mice exhibit reduced grip strength compared to wild-type mice

decreased locomotor activity ( J:141962 )

• mice exhibit reduced locomotion in new and familiar environments compared to wild-type mice

nervous system

nervous system phenotype ( J:141962 )

N • mice exhibit normal brain morphology and levels of serotonine and dopamine are normal

abnormal neuron morphology ( J:141962 )

• neurons have smaller growth cones with reduced widths compare to wild-type growth cones and they extend along the shaft unlike growth cones

abnormal neurite morphology ( J:141962 )

• young and old cultured neurons have fewer, shorter neurites than wild-type neurons

reproductive system

reproductive system phenotype ( J:141962 )

N • mice are fertile and male mice exhibit normal testes morphology