Phenotypes associated with this allele

• Allele Symbol: Cd44^tm1.1Ugu
• Allele Name: targeted mutation 1.1, Ursula Gunthert
• Allele ID: MGI:2679706
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	B6.129(Cg)-Cd44^tm1.1Ugu	MGI:5523443
hm2	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	involves: 129/Sv * C57BL/6	MGI:2679730
hm3	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu	SJL.129(Cg)-Cd44^tm1.1Ugu	MGI:5523444
cx4	Cd44^tm1.1Ugu/Cd44^tm1.1Ugu Il10^tm1Cgn/Il10^tm1Cgn	involves: 129/Sv * C57BL/6	MGI:2679731

Genotype
MGI:5523443

hm1

• Allelic Composition: Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
• Genetic Background: B6.129(Cg)-Cd44^tm1.1Ugu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199279 )

• with reduced symptoms, fewer inflammatory infiltrates and increased apoptotic activity

Genotype
MGI:2679730

hm2

• Allelic Composition: Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
• Genetic Background: involves: 129/Sv * C57BL/6

digestive/alimentary system

abnormal digestive system physiology ( J:62867 )

• 3-4X increase of apoptotic cells in colons after injury but not without injury

immune system

immune system phenotype ( J:62867 )

N • 78% as opposed to 44% of mice survived acute colon injury and did not develop colitis

abnormal T-helper 1 physiology ( J:62867 )

• Th1-type cytokines down regulated

abnormal T-helper 2 physiology ( J:62867 )

• Th2-type cytokines up regulated

hematopoietic system

abnormal T-helper 1 physiology ( J:62867 )

• Th1-type cytokines down regulated

abnormal T-helper 2 physiology ( J:62867 )

• Th2-type cytokines up regulated

Genotype
MGI:5523444

hm3

• Allelic Composition: Cd44^tm1.1Ugu/Cd44^tm1.1Ugu
• Genetic Background: SJL.129(Cg)-Cd44^tm1.1Ugu

immune system

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:199279 )

• delayed onset with reduced symptoms, fewer inflammatory infiltrates and increased apoptotic activity

hematopoietic system

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

cellular

decreased T cell proliferation ( J:199279 )

• of lymph node T cells repeatedly stimulated with PLP139-151

Genotype
MGI:2679731

cx4

• Allelic Composition: Cd44^tm1.1Ugu/Cd44^tm1.1Ugu; Il10^tm1Cgn/Il10^tm1Cgn
• Genetic Background: involves: 129/Sv * C57BL/6

growth/size/body

weight loss ( J:62867 )

• normal until 24 weeks of age when they start losing weight

• life span normal in spite of weight loss

immune system

abnormal immune system physiology ( J:62867 )

• only small areas of inflammation in the mucosa