Phenotypes associated with this allele

• Allele Symbol: Zbtb17^tm1Elr
• Allele Name: targeted mutation 1, Martin Eilers
• Allele ID: MGI:2679766
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb17^tm1Elr/Zbtb17^tm1Elr	involves: 129X1/SvJ * C57BL/6	MGI:2679782

Genotype
MGI:2679782

hm1

• Allelic Composition: Zbtb17^tm1Elr/Zbtb17^tm1Elr
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:86265 )

• homozygous mutant embryos die prior to E8.5

• first signs of resorption become apparent at E7.5

• a few severely retarded embryos are detected at E9 and E8.5, in addition to remnants of resorbed embryos

embryo

abnormal developmental patterning ( J:86265 )

• homozygotes exhibit defects in early embryonic development during gastrulation

• however, induction of mesoderm is apparently intact

abnormal ectoderm development ( J:86265 )

• massive apoptosis of ectodermal cells around E8

failure to gastrulate ( J:86265 )

• at E7.5, 93% of mutant embryos fail to undergo proper gastrulation

embryonic growth retardation ( J:86265 )

• a few severely retarded embryos are detected at E9 and E8.5, in addition to remnants of resorbed embryos

decreased embryo size ( J:86265 )

• at E7.5, mutant embryos are generally much smaller than control embryos

abnormal embryonic tissue morphology ( J:86265 )

• at E6.5, the embryonic region is smaller in size and reduced in cell number

abnormal primitive streak morphology ( J:86265 )

• a primitive streak is visible in some but not all mutant embryos

abnormal extraembryonic tissue morphology ( J:86265 )

• at E6.5, the extraembryonic region is smaller in size and reduced in cell number

absent proamniotic cavity ( J:86265 )

• at E6.5, the proamniotic cavity is absent

growth/size/body

embryonic growth retardation ( J:86265 )

• a few severely retarded embryos are detected at E9 and E8.5, in addition to remnants of resorbed embryos

decreased embryo size ( J:86265 )

• at E7.5, mutant embryos are generally much smaller than control embryos

cellular

increased apoptosis ( J:86265 )

• massive apoptosis of ectodermal cells that contact the basal membrane at E7.5 and E8.0, as shown by TUNEL staining

decreased cell proliferation ( J:86265 )

• reduced BrdU incorporation in mutant embryos at E7.0