About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptentm2Ppp
targeted mutation 2, Pier Paolo Pandolfi
MGI:2679885
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ptentm1Ppp/Ptentm2Ppp involves: 129S1/Sv * C57BL/6 MGI:2679895


Genotype
MGI:2679895
ht1
Allelic
Composition		 Ptentm1Ppp/Ptentm2Ppp
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (88 available)
Ptentm2Ppp mutation (0 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:86212 )
• incomplete penetrance
• 40% of males died in utero
• 75% of females died in utero

neoplasm
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

endocrine/exocrine glands
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

reproductive system
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory