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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iglc1tm1Ust
targeted mutation 1, Ursula Storb
MGI:2680012
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iglc1tm1Ust/Iglc1tm1Ust involves: 129S7/SvEvBrd * C57BL/6 MGI:3719656
cx2
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1tm1Ust 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3719654
cx3
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1+ 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3719658


Genotype
MGI:3719656
hm1
Allelic
Composition		 Iglc1tm1Ust/Iglc1tm1Ust
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell number ( J:68144 )
• kappa B cells numbers are decreased and lambda B cell numbers are increased
• the kappa to lambda B cell ratio is altered from 8:1 in wild-type mice to 20:1

hematopoietic system
abnormal B cell number ( J:68144 )
• kappa B cells numbers are decreased and lambda B cell numbers are increased
• the kappa to lambda B cell ratio is altered from 8:1 in wild-type mice to 20:1




Genotype
MGI:3719654
cx2
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1tm1Ust
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen
• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice
• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice

hematopoietic system
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen
• the ratios of lambda1 to lambda2/3 B cells in the bone marrow and spleen is increased to 14.9 and 11.9, respectively, from 1.5 and 1.1 in wild-type mice
• lambda1 B cells percentages are increased to 82% compared to 54% in wild-type mice




Genotype
MGI:3719658
cx3
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm1Ust/Iglc1+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:68144 )
• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

hematopoietic system
abnormal B cell differentiation ( J:68144 )
• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen
increased B cell number ( J:68144 )
• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory