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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iglc1tm1.1Ust
targeted mutation 1.1, Ursula Storb
MGI:2680013
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1tm1.1Ust 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3719655
cx2
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1+ 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:3719657


Genotype
MGI:3719655
cx1
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1tm1.1Ust
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm1.1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:68144 )
• lambda1 B cell numbers are reduced to 15.8% from 92.2% in Igl-C1tm1Ust/ Igl-C1tm1Ust Igktm1Dhu/ Igktm1Dhu mice
• lambda1 B cell numbers are lower than in wild-type mice (15.8% compared with 52.5% in wild-type mice)

hematopoietic system
decreased B cell number ( J:68144 )
• lambda1 B cell numbers are reduced to 15.8% from 92.2% in Igl-C1tm1Ust/ Igl-C1tm1Ust Igktm1Dhu/ Igktm1Dhu mice
• lambda1 B cell numbers are lower than in wild-type mice (15.8% compared with 52.5% in wild-type mice)




Genotype
MGI:3719657
cx2
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm1.1Ust/Iglc1+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm1.1Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:68144 )
• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1tm1Ust/ Igl-C1+ Igktm1Dhu/ Igktm1Dhu mice

hematopoietic system
decreased B cell number ( J:68144 )
• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1tm1Ust/ Igl-C1+ Igktm1Dhu/ Igktm1Dhu mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory