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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acvrl1tm1Spo
targeted mutation 1, S Paul Oh
MGI:2680088
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Acvrl1tm1Spo/Acvrl1tm1Spo involves: 129S4/SvJae * C57BL/6 MGI:2680089
ht2
 		Acvrl1tm1Spo/Acvrl1tm2Spo involves: 129 * 129S4/SvJae * C57BL/6 MGI:4398915
ht3
 		Acvrl1tm1Spo/Acvrl1tm1Enl involves: 129S4/SvJae * C57BL/6 MGI:2680090


Genotype
MGI:2680089
hm1
Allelic
Composition		 Acvrl1tm1Spo/Acvrl1tm1Spo
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm1Spo mutation (0 available); any Acvrl1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal vascular development ( J:85877 )
• severe vascular defects at E9.5-E10.5 when homozygotes die




Genotype
MGI:4398915
ht2
Allelic
Composition		 Acvrl1tm1Spo/Acvrl1tm2Spo
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm1Spo mutation (0 available); any Acvrl1 mutation (27 available)
Acvrl1tm2Spo mutation (0 available); any Acvrl1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130020 )
• mice are viable




Genotype
MGI:2680090
ht3
Allelic
Composition		 Acvrl1tm1Spo/Acvrl1tm1Enl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvrl1tm1Enl mutation (0 available); any Acvrl1 mutation (27 available)
Acvrl1tm1Spo mutation (0 available); any Acvrl1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:85877 )
• heterozygotes die around E9.5-E10.5

cardiovascular system
abnormal vascular development ( J:85877 )
• severe vascular defects at E9.5-E10.5 when heterozygotes die




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory