Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Xu
• Allele Name: targeted mutation 1, Yang Xu
• Allele ID: MGI:2680218
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Xu/Trp53^tm1Xu	involves: 129S4/SvJae	MGI:2680222
cx2	Trp53^tm1Xu/Trp53^tm1Xu Xrcc4^tm1Fwa/Xrcc4^tm1Fwa	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3630331

Genotype
MGI:2680222

hm1

• Allelic Composition: Trp53^tm1Xu/Trp53^tm1Xu
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:86185 )

N • no increase of spontaneous tumorigenesis in spite of impaired transcriptional and apoptotic responses

hematopoietic system

abnormal thymocyte apoptosis ( J:86185 )

• apoptosis is impaired in thymocytes after ionizing radiation

immune system

abnormal thymocyte apoptosis ( J:86185 )

• apoptosis is impaired in thymocytes after ionizing radiation

cellular

decreased cellular sensitivity to ionizing radiation ( J:86185 )

• apoptosis that normally occurs after ionizing radiation is impaired in thymocytes

decreased cellular sensitivity to ultraviolet irradiation ( J:86185 )

• MEFs are impaired in the G1/S cell cycle arrest observed in wild-type mice after UV radiation

abnormal thymocyte apoptosis ( J:86185 )

• apoptosis is impaired in thymocytes after ionizing radiation

endocrine/exocrine glands

abnormal thymocyte apoptosis ( J:86185 )

• apoptosis is impaired in thymocytes after ionizing radiation

Genotype
MGI:3630331

cx2

• Allelic Composition: Trp53^tm1Xu/Trp53^tm1Xu; Xrcc4^tm1Fwa/Xrcc4^tm1Fwa
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

mortality/aging

mortality/aging ( J:109354 )

N • embryonic lethality seen in Xrcc4^tm1Fwa homozygotes is rescued at a low frequency when crossed to a Trp53^tm1Xu mouse

cellular

abnormal apoptosis ( J:109354 )

• Trp53-dependent apoptosis in thymocytes is partially impaired after irradiation