Phenotypes associated with this allele

• Allele Symbol: Sh2b2^tm1Yeb
• Allele Name: targeted mutation 1, Yousuke Ebina
• Allele ID: MGI:2680256
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2b2^tm1Yeb/Sh2b2^tm1Yeb	involves: C57BL/6	MGI:2680268

Genotype
MGI:2680268

hm1

• Allelic Composition: Sh2b2^tm1Yeb/Sh2b2^tm1Yeb
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:88527 )

• IgM+ CD5+ and B220+ Il5Ralpha+ cells are over represented

increased B-1 B cell number ( J:88527 )

• slight increase in B-1 cells by peritoneal lavage

increased IgG3 level ( J:88527 )

• slight increase of serum IgG3 levels

homeostasis/metabolism

decreased circulating insulin level ( J:86301 )

• reduced plasma levels of insulin accompanied by increased insulin sensitivity

immune system

abnormal B cell differentiation ( J:88527 )

• IgM+ CD5+ and B220+ Il5Ralpha+ cells are over represented

increased B-1 B cell number ( J:88527 )

• slight increase in B-1 cells by peritoneal lavage

increased IgG3 level ( J:88527 )

• slight increase of serum IgG3 levels