All Phenotypes Rpe65<450M> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rpe65^450M
450 Methionine
MGI:2680347

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpe65^450M/Rpe65^450M	C57BL/6J-Tyr^c-2J	MGI:2680428
cx2	Rpe65^450M/Rpe65^450M Rpgr^tm1Wbrg/Rpgr^tm1Wbrg	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:4458095
cx3	Lrat^tm1Kpal/Lrat^tm1Kpal Rho^tm1.1Kpal/Rho⁺ Rpe65^450L/Rpe65^450M	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4947236

Allelic Composition	Rpe65^450M/Rpe65^450M
Genetic Background	C57BL/6J-Tyr^c-2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65^450M mutation (2 available); any Rpe65 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye physiology ( J:86186 )

• decreased rod photoreceptor gain relative to BALB/cByJ

• increased latency to recovery from photobleach relative to BALB/cByJ

Allelic Composition	Rpe65^450M/Rpe65^450M Rpgr^tm1Wbrg/Rpgr^tm1Wbrg
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpe65^450M mutation (2 available); any Rpe65 mutation (52 available)
Rpgr^tm1Wbrg mutation (0 available); any Rpgr mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye morphology ( J:160802 )

• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations

abnormal eye physiology ( J:160802 )

• authors state that mice exhibit the same eye phenotype as observed when mice are backcrossed to BALB/c for 8 generations

Allelic Composition	Lrat^tm1Kpal/Lrat^tm1Kpal Rho^tm1.1Kpal/Rho⁺ Rpe65^450L/Rpe65^450M
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrat^tm1Kpal mutation (1 available); any Lrat mutation (26 available)
Rho^tm1.1Kpal mutation (1 available); any Rho mutation (51 available)
Rpe65^450L mutation (1 available); any Rpe65 mutation (52 available)
Rpe65^450M mutation (2 available); any Rpe65 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Effect of genetic depletion of 11-cis-retinal production (Lrat^tm1Kpal/Lrat^tm1Kpal) on retinal degeneration in Rho^tm1.1Kpal/Rho⁺ mice

vision/eye

decreased retina photoreceptor cell number ( J:170648 )

• dramatically reduced at P36

abnormal retina rod cell outer segment morphology ( J:170648 )

• less than in Rho^tm1.1Kpal heterozygotes

retina photoreceptor degeneration ( J:170648 )

• due to increased apoptosis

retina rod cell degeneration ( J:170648 )

• less than in Rho^tm1.1Kpal heterozygotes

thin retina outer nuclear layer ( J:170648 )

retina degeneration ( J:170648 )

• at P36

nervous system

decreased retina photoreceptor cell number ( J:170648 )

• dramatically reduced at P36

abnormal retina rod cell outer segment morphology ( J:170648 )

• less than in Rho^tm1.1Kpal heterozygotes

retina photoreceptor degeneration ( J:170648 )

• due to increased apoptosis

retina rod cell degeneration ( J:170648 )

• less than in Rho^tm1.1Kpal heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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