Phenotypes associated with this allele

• Allele Symbol: Pla2g12b^hlb218
• Allele Name: heart, lung and blood, 218
• Allele ID: MGI:2680455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g12b^hlb218/Pla2g12b^hlb218	C57BL/6J-Pla2g12b^hlb218/J	MGI:2680456

Genotype
MGI:2680456

hm1

• Allelic Composition: Pla2g12b^hlb218/Pla2g12b^hlb218
• Genetic Background: C57BL/6J-Pla2g12b^hlb218/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased liver lipid level in Pla2g12b^hlb218/Pla2g12b^hlb218 mice

homeostasis/metabolism

decreased circulating cholesterol level ( J:82961 , J:187708 )

• low serum levels reported: 4 hour fasted plasma total cholesterol of 17 mg/dl (J:82961)

decreased circulating HDL cholesterol level ( J:82961 , J:187708 )

• 4 hour fasted HDL = 15 mg/dl at 8 weeks of age (J:82961)

• a 92% decrease in HDL cholesterol (J:187708)

decreased circulating triglyceride level ( J:187708 )

• a 58% decrease in triglyceride levels

liver/biliary system

hepatic steatosis ( J:187708 )

♀ • increased accumulation of fat droplets in the liver in females