Analysis Tools
hematopoietic system
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• two of three mice showed minor splenomegaly upon necroscopy
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• mutant bone marrow cells gave rise to significantly smaller CFU-granulocyte-macrophage (CFU-GM) and CFU-granulocyte (CFU-G) than controls
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• mutant bone marrow cells gave rise to significantly smaller CFU-granulocyte-erythrocyte-monocytemacrophage (CFU-GEMM) than controls
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• mutant mice exhibit a decreased number of megakaryocytes in the bone marrow
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• mutant bone marrow cells gave rise to significantly smaller CFU-Mk populations than controls
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• significantly fewer red blood cells compared to controls
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• mice had a platelet count of 106 X 103 cells/ul at 6 weeks of age
(J:82961)
• the platelet level is reduced by approximately 80% in comparison to controls
(J:146577)
• platelet morphology is normal and there is no sign of platelet aggregation in blood smears stained with Wright-Giemsa
(J:146577)
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• lower white blood cells counts than controls
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homeostasis/metabolism
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• circulating thrombopoietin (TPO) levels in mutant mice are approximately 10 times higher than in controls
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• an increase in tail vein bleeding time is seen, but no obvious signs of excessive bleeding are noted
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immune system
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• two of three mice showed minor splenomegaly upon necroscopy
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• lower white blood cells counts than controls
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• circulating thrombopoietin (TPO) levels in mutant mice are approximately 10 times higher than in controls
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growth/size/body
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• two of three mice showed minor splenomegaly upon necroscopy
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