Phenotypes associated with this allele

• Allele Symbol: Tg(rPEPCKSREBF2)788Reh
• Allele Name: transgene insertion 788, Robert E Hammer
• Allele ID: MGI:2680523
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(rPEPCKSREBF2)788Reh/0	Not Specified	MGI:3603466

Genotype
MGI:3603466

tg1

• Allelic Composition: Tg(rPEPCKSREBF2)788Reh/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:86518 )

• sterol synthesis in livers increased 28%

increased circulating cholesterol level ( J:86518 )

• plasma cholesterol elevated in hemizygous animals

increased liver cholesterol level ( J:86518 )

• liver cholesterol levels elevated 11-fold

• elevated expression of cholesterol biosynthesis genes, particularly HMG CoA reductase

• increased expression of LDL receptor

increased fatty acids level ( J:86518 )

• fatty acid synthesis increased 4-fold

increased liver triglyceride level ( J:86518 )

• liver triglycerides elevated

• increased expression of microsomal triglyceride transfer protein

liver/biliary system

increased liver cholesterol level ( J:86518 )

• liver cholesterol levels elevated 11-fold

• elevated expression of cholesterol biosynthesis genes, particularly HMG CoA reductase

• increased expression of LDL receptor

increased liver triglyceride level ( J:86518 )

• liver triglycerides elevated

• increased expression of microsomal triglyceride transfer protein

pale liver ( J:86518 )