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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nod2tm1Pmu
targeted mutation 1, Peter J Murray
MGI:2680581
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nod2tm1Pmu/Nod2tm1Pmu involves: BALB/c * C57BL/6 MGI:2680589


Genotype
MGI:2680589
hm1
Allelic
Composition		 Nod2tm1Pmu/Nod2tm1Pmu
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nod2tm1Pmu mutation (0 available); any Nod2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:86264 )
• normal response to most activating and deactivating stimuli
• failure to respond to muramyl dipeptide stimulation
• no Il12 secretion
decreased susceptibility to endotoxin shock ( J:86264 )
• enhanced survival of endotoxic shock from higher doses of bacterial lipopolysaccharide under some conditions

hematopoietic system
abnormal macrophage physiology ( J:86264 )
• normal response to most activating and deactivating stimuli
• failure to respond to muramyl dipeptide stimulation
• no Il12 secretion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory