About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gabrg2tm2Lusc
targeted mutation 2, Bernhard Luscher
MGI:2680624
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gabrg2tm2Lusc/Gabrg2tm2Lusc involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680628
cn2
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:2680627
cn3
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)T50Stl/0
involves: 129X1/SvJ * BALB/c * C57BL/6 MGI:2680635


Genotype
MGI:2680628
hm1
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2680627
cn2
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a rapid decline in health is observed by the end of the fourth postnatal week and mice die within 3 days of overt signs of stress including reduced locomotion, round pupils, and reduced weight gain

behavior/neurological
• lack of locomotion is observed as health declines
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions

nervous system
• some mice exhibit overt epilepsy within several days prior to death; typical seizures start with rearing adn loss of postural control, followed by running fits and violent convulsions




Genotype
MGI:2680635
cn3
Allelic
Composition
Gabrg2tm2Lusc/Gabrg2tm2Lusc
Tg(Camk2a-cre)T50Stl/0
Genetic
Background
involves: 129X1/SvJ * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm2Lusc mutation (1 available); any Gabrg2 mutation (41 available)
Tg(Camk2a-cre)T50Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 7 weeks of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory