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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa3tm3Mrc
targeted mutation 3, Mario R Capecchi
MGI:2680649
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxa3tm3Mrc/Hoxa3tm3Mrc Not Specified MGI:2680651
cx2
 		Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxd3tm2Mrc/Hoxd3tm2Mrc 		involves: 129S1/Sv * 129X1/SvJ MGI:3836914
cx3
 		Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc 		involves: 129S4/SvJae MGI:3836912


Genotype
MGI:2680651
hm1
Allelic
Composition		 Hoxa3tm3Mrc/Hoxa3tm3Mrc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm3Mrc mutation (0 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic motor system morphology ( J:86041 )
• reduced number of somatic motor neurons arising from r5




Genotype
MGI:3836914
cx2
Allelic
Composition		 Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxd3tm2Mrc/Hoxd3tm2Mrc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm3Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxd3tm2Mrc mutation (0 available); any Hoxd3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:86041 )
• migration of facial branchiomotor neurons from r6 to r7
abnormal somatic motor system morphology ( J:86041 )
• ectopic appearance of facial branchiomotor neurons in r6

cellular
abnormal neuronal migration ( J:86041 )
• migration of facial branchiomotor neurons from r6 to r7




Genotype
MGI:3836912
cx3
Allelic
Composition		 Hoxa3tm3Mrc/Hoxa3tm3Mrc
Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3tm3Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxb3tm1Mrc mutation (0 available); any Hoxb3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic motor system morphology ( J:86041 )
• incomplete loss of somatic motor neurons restricted to r5
• possibly involving a "change of fate" to V2 interneurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory